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Hemoglobin Gamma 2 (HBg2)

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Gamma-2-globin

Hemoglobin Gamma 2 (HBg2)
CCC D095
HGNC 4832
PubMed 24483321
UniProt P69892
Wiki HBG2
Hemoglobin subunit gamma-2 is a protein that in humans is encoded by the HBG2 gene. The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood.
The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD095Hu01 Recombinant Hemoglobin Gamma 2 (HBg2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD095Hu01 Polyclonal Antibody to Hemoglobin Gamma 2 (HBg2) WB; IHC; ICC; IP.
MAD095Hu21 Monoclonal Antibody to Hemoglobin Gamma 2 (HBg2) WB; IHC; ICC; IP.
Assay Kits SED095Hu ELISA Kit for Hemoglobin Gamma 2 (HBg2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes."Cell 21:627-638(1980) [PubMed] [Europe PMC] [Abstract]
  2. "Nucleotide sequence of human G gamma globin messenger RNA."Gene 12:215-221(1980) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The amino acid sequence of the gamma chain of human fetal hemoglobin."Biochemistry 2:992-1008(1963) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (DEC-2008) to UniProtKB
  7. "Cloning specific complete polyadenylylated 3'-terminal cDNA segments."Gene 33:191-196(1985) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of human foetal deoxyhaemoglobin."J. Mol. Biol. 112:97-112(1977) [PubMed] [Europe PMC] [Abstract]
  10. "Human fetal hemoglobin F 1. Acetylation status."J. Biol. Chem. 246:3001-3007(1971) [PubMed] [Europe PMC] [Abstract]
  11. "Haemoglobin F(Malta): a new foetal haemoglobin variant with a high incidence in Maltese infants."Nature 223:311-313(1969) [PubMed] [Europe PMC] [Abstract]
  12. "Haemoglobin F Auckland G gamma 7 Asp leads to Asn: further evidence for multiple genes for the gamma chain."Biochim. Biophys. Acta 365:323-327(1974) [PubMed] [Europe PMC] [Abstract]
  13. "Haemoglobin F Port Royal (alpha2G gamma2 125 Glu leads to Ala)."Br. J. Haematol. 27:313-318(1974) [PubMed] [Europe PMC] [Abstract]
  14. "Haemoglobin F Malaysia: alpha 2, gamma 2 1(NA1) glycine-->cysteine; 136 glycine."J. Med. Genet. 11:25-30(1974) [PubMed] [Europe PMC] [Abstract]
  15. "A new cause of haemolytic anaemia in the newborn. A description of an unstable fetal haemoglobin: F Poole, alpha2-G-gamma2 130 tryptophan yields glycine."J. Clin. Pathol. 28:317-320(1975) [PubMed] [Europe PMC] [Abstract]
  16. "Haemoglobin F Melbourne Ggamma 16 Gly leads to Arg and haemoglobin F carlton Ggamma 121 Glu leads to Lys. Further evidence for varied activity of gamma-chain genes."Biochim. Biophys. Acta 490:452-455(1977) [PubMed] [Europe PMC] [Abstract]
  17. "Hb F-Meinohama or alpha 2 gamma 2 (5 Glu replaced by Gly; 75 Ile; 136 Gly)."Hemoglobin 5:565-570(1981) [PubMed] [Europe PMC] [Abstract]
  18. "Hemoglobin F Lodz (G gamma I 44 Ser replaced by Arg). A newly identified variant from an American infant of Polish descent."Biochim. Biophys. Acta 707:213-216(1982) [PubMed] [Europe PMC] [Abstract]
  19. "Hb F Kingston (G gamma 55 [D6] Met leads to Arg)."FEBS Lett. 150:77-80(1982) [PubMed] [Europe PMC] [Abstract]
  20. "Hemoglobin F-Caltech: alpha 2 G gamma 2 120Lys replaced by Gln."Hemoglobin 6:577-592(1982) [PubMed] [Europe PMC] [Abstract]
  21. "Hb F-Columbus-Ga or alpha 2 G gamma 2 94(FGl) Asp replaced by Asn."Hemoglobin 6:593-598(1982) [PubMed] [Europe PMC] [Abstract]
  22. "Hb F-Kennestone or alpha 2G gamma 2 (EF1)77 His leads to Arg observed in a Caucasian baby."Hemoglobin 7:267-270(1983) [PubMed] [Europe PMC] [Abstract]
  23. "Hb F-La Grange or alpha 2 gamma 2 101(G3)Glu-->Lys; 75Ile; 136Gly: a high oxygen affinity fetal hemoglobin variant observed in a Caucasian newborn."Biochim. Biophys. Acta 789:224-228(1984) [PubMed] [Europe PMC] [Abstract]
  24. "-G gamma A gamma-thalassemia and gamma-chain variants in Chinese newborn babies."Am. J. Hematol. 18:235-242(1985) [PubMed] [Europe PMC] [Abstract]
  25. "Hb F-Tokyo or alpha 2G gamma 2 34(B16)Val-->Ile, a silent gamma chain variant detected by reverse phase high performance liquid chromatography."Hemoglobin 9:25-32(1985) [PubMed] [Europe PMC] [Abstract]
  26. "Hb F-Urumqi G gamma I22(B4)Asp-->Gly: a new fetal hemoglobin variant found in a Uygur baby."Hemoglobin 10:15-20(1986) [PubMed] [Europe PMC] [Abstract]
  27. "Hb F-Albaicin or G gamma 8(A5)Lys-->Glu or Gln."Hemoglobin 10:655-659(1986) [PubMed] [Europe PMC] [Abstract]
  28. "Neonatal screening and mass-spectrometric analysis of hemoglobin variants in Japan."Acta Haematol. 78:114-118(1987) [PubMed] [Europe PMC] [Abstract]
  29. "Hb F-Oakland or alpha 2G gamma I2(26)(B8)Glu-->Lys."Hemoglobin 11:181-183(1987) [PubMed] [Europe PMC] [Abstract]
  30. "Hb F-Clarke or alpha 2G gamma 2(65)(E9)Lys-->Asn."Hemoglobin 11:185-188(1987) [PubMed] [Europe PMC] [Abstract]
  31. "Hb F-Granada or alpha 2G gamma (2)22(B4)Asp-->Val: a new human fetal hemoglobin variant."Hemoglobin 12:405-407(1988) [PubMed] [Europe PMC] [Abstract]
  32. "Hb F-Austell or alpha 2G gamma (2)40(C6)Arg-->Lys."Hemoglobin 12:409-411(1988) [PubMed] [Europe PMC] [Abstract]
  33. "Hb F-M-Osaka or alpha 2G gamma 2(63)(E7)His-->Tyr in a Caucasian male infant."Hemoglobin 13:769-773(1989) [PubMed] [Europe PMC] [Abstract]
  34. "Mutant fetal hemoglobin causing cyanosis in a newborn."Pediatrics 83:734-736(1989) [PubMed] [Europe PMC] [Abstract]
  35. "Hb F-Brooklyn or alpha 2G gamma 2(66)(E10)Lys-->Gln."Hemoglobin 14:213-216(1990) [PubMed] [Europe PMC] [Abstract]
  36. "Hb F-Onoda or alpha 2G gamma 2(146)(HC3)His-->Tyr, a newly discovered fetal hemoglobin variant in a Japanese newborn."Hemoglobin 14:217-222(1990) [PubMed] [Europe PMC] [Abstract]
  37. "Hb F-Catalonia or alpha 2G gamma(2)15(A12)Trp-->Arg."Hemoglobin 14:511-516(1990) [PubMed] [Europe PMC] [Abstract]
  38. "Hb F-Charlotte, an A gamma variant with a threonine residue in position gamma 75 and a glycine residue in position gamma 136."Hemoglobin 14:617-625(1990) [PubMed] [Europe PMC] [Abstract]
  39. "Hb F-Cosenza or G gamma 25(B7)Gly-->Glu: a new fast-moving fetal hemoglobin variant."Hemoglobin 15:509-515(1991) [PubMed] [Europe PMC] [Abstract]
  40. "Hb F-Saskatoon or alpha 2G gamma (2)21(B3)Glu-->Lys observed in a North American indian newborn."Hemoglobin 17:547-549(1993) [PubMed] [Europe PMC] [Abstract]
  41. "Hb F-Macedonia-II [G gamma 104(G6)Lys-->Asn]: a new gamma chain variant."Hemoglobin 18:373-382(1994) [PubMed] [Europe PMC] [Abstract]
  42. "Hemoglobin F-Cincinnati, alpha 2G gamma 2 41(C7) Phe-->Ser in a newborn with cyanosis."Am. J. Hematol. 49:43-47(1995) [PubMed] [Europe PMC] [Abstract]
  43. "Two fetal hemoglobin variants affecting the same residue: Hb F-Emirates [G gamma 59(E3)Lys-->Glu] and Hb F-Sacromonte [G gamma 59(E3)Lys-->Gln]."Hemoglobin 19:173-182(1995) [PubMed] [Europe PMC] [Abstract]
  44. "Hb F-Veleta or alpha 2 G gamma(2)40(C6)Arg-->Gly."Hemoglobin 19:407-411(1995) [PubMed] [Europe PMC] [Abstract]
  45. "The G gamma T chain (G gamma 75 Thr; 136 Gly) in Hb F-Charlotte is the product of an A gamma gene with a limited gene conversion and that in Hb F-Waynesboro of a mutated G gamma gene."Hemoglobin 19:413-418(1995) [PubMed] [Europe PMC] [Abstract]
  46. "HbF-Lesvos: an HbF variant due to a novel G gamma mutation (G gamma 75 ATA-->ACA) detected in a Greek family."Hum. Genet. 97:260-262(1996) [PubMed] [Europe PMC] [Abstract]
  47. "A new, electrophoretically silent, fetal hemoglobin variant: Hb F-Calabria Ggamma118(GH1)Phe-->Leu."Hemoglobin 24:37-44(2000) [PubMed] [Europe PMC] [Abstract]
  48. "Two new Ggamma chain variants: Hb F-Clamart [gamma17(A14)Lys-->Asn] and Hb F-Ouled Rabah [gamma19(B1)Asn-->Lys]."Hemoglobin 24:45-52(2000) [PubMed] [Europe PMC] [Abstract]
  49. "A new Ggamma chain variant: Hb F-Coignieres [gamma75(E19)Ile-->Val]."Hemoglobin 25:425-428(2001) [PubMed] [Europe PMC] [Abstract]
  50. "Severe hereditary haemolytic anaemia in a Caucasian newborn: a new fetal haemoglobin variant Hb F-Bonheiden ((G)gamma 38(C4) Thr-->Pro)."Eur. J. Pediatr. 164:261-262(2005) [PubMed] [Europe PMC] [Abstract]
  51. "A new G(gamma) chain variant: Hb F-Bron [gamma20(B2)Val-->Ala]."Hemoglobin 29:301-305(2005) [PubMed] [Europe PMC] [Abstract]
  52. "Neonatal cyanosis due to a novel fetal hemoglobin: Hb F-Circleville [Ggamma63(E7)His-->Leu, CAT>CTT]."Hemoglobin 32:596-600(2008) [PubMed] [Europe PMC] [Abstract]
  53. "A hemoglobin variant associated with neonatal cyanosis and anemia."N. Engl. J. Med. 364:1837-1843(2011) [PubMed] [Europe PMC] [Abstract]
  54. "A new (G)gamma-globin variant causing low oxygen affinity: Hb F-Brugine/Feldkirch [(G)gamma105(G7)Leu?His; HBG2: c.317T>A]."Hemoglobin 38:84-87(2014) [PubMed] [Europe PMC] [Abstract]