-93098.jpg)
Beta globin (HBB, β-globin) is a protein that, along with alpha globin (HBA), makes up the most common form of hemoglobin in adult humans. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains.
The gene is located in the β-globin locus. Expression of beta globin and the neighboring globins in the β-globin locus is controlled by single locus control region (LCR). The order of the genes in the beta-globin cluster is 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'. Mutant beta globin is responsible for the sickling of red blood cells seen in sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD098Hu01 | Recombinant Hemoglobin Beta (HBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPD098Hu02 | Recombinant Hemoglobin Beta (HBb) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAD098Hu01 | Polyclonal Antibody to Hemoglobin Beta (HBb) | WB; IHC; ICC; IP. |
| MAD098Hu21 | Monoclonal Antibody to Hemoglobin Beta (HBb) | WB | |
| Assay Kits | CED098Hu | ELISA Kit for Hemoglobin Beta (HBb) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD098Mu01 | Recombinant Hemoglobin Beta (HBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAD098Mu01 | Polyclonal Antibody to Hemoglobin Beta (HBb) | WB; IHC |
| LAD098Mu71 | Biotin-Linked Polyclonal Antibody to Hemoglobin Beta (HBb) | WB; IHC; ICC. | |
| Assay Kits | n/a | CLIA Kit for Hemoglobin Beta (HBb) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hemoglobin Beta (HBb) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Hemoglobin Beta (HBb) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Hemoglobin Beta (HBb) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Hemoglobin Beta (HBb) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Hemoglobin Beta (HBb) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hemoglobin Beta (HBb) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD098Bo01 | Recombinant Hemoglobin Beta (HBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAD098Bo01 | Polyclonal Antibody to Hemoglobin Beta (HBb) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Hemoglobin Beta (HBb) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hemoglobin Beta (HBb) | ELISA Kit Customized Service Offer |
Organism species: Ovis aries; Ovine (Sheep)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD098Ov01 | Recombinant Hemoglobin Beta (HBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NPD098Ov01 | Native Hemoglobin Beta (HBb) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAD098Ov01 | Polyclonal Antibody to Hemoglobin Beta (HBb) | WB; IHC; ICC; IP. |
| LAD098Ov71 | Biotin-Linked Polyclonal Antibody to Hemoglobin Beta (HBb) | WB; IHC; ICC. | |
| MAD098Ov21 | Monoclonal Antibody to Hemoglobin Beta (HBb) | WB; IHC; ICC; IP. | |
| PAD098Ov02 | Polyclonal Antibody to Hemoglobin Beta (HBb) | WB; IHC; ICC; IP. | |
| Assay Kits | n/a | CLIA Kit for Hemoglobin Beta (HBb) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hemoglobin Beta (HBb) | ELISA Kit Customized Service Offer |
Organism species: Equus caballus; Equine (Horse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD098Eq01 | Recombinant Hemoglobin Beta (HBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAD098Eq01 | Polyclonal Antibody to Hemoglobin Beta (HBb) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Hemoglobin Beta (HBb) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hemoglobin Beta (HBb) | ELISA Kit Customized Service Offer |
Organism species: Chicken (Gallus)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPD098Ga01 | Recombinant Hemoglobin Beta (HBb) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAD098Ga01 | Polyclonal Antibody to Hemoglobin Beta (HBb) | WB; IHC; ICC; IP. |
| LAD098Ga71 | Biotin-Linked Polyclonal Antibody to Hemoglobin Beta (HBb) | WB; IHC; ICC. | |
| MAD098Ga21 | Monoclonal Antibody to Hemoglobin Beta (HBb) | WB; IHC; ICC; IP. | |
| LAD098Ga81 | FITC-Linked Polyclonal Antibody to Hemoglobin Beta (HBb) | WB; IHC; ICC; IF. | |
| Assay Kits | n/a | CLIA Kit for Hemoglobin Beta (HBb) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hemoglobin Beta (HBb) | ELISA Kit Customized Service Offer |
- "Nucleotide sequence analysis of coding and noncoding regions of human beta-globin mRNA."Prog. Nucleic Acid Res. Mol. Biol. 19:165-175(1976) [PubMed] [Europe PMC] [Abstract]
- "The nucleotide sequence of the human beta-globin gene."Cell 21:647-651(1980) [PubMed] [Europe PMC] [Abstract]
- "The beta-globin recombinational hotspot reduces the effects of strong selection around HbC, a recently arisen mutation providing resistance to malaria."Am. J. Hum. Genet. 77:637-642(2005) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The constitution of normal adult human haemoglobin."Hoppe-Seyler's Z. Physiol. Chem. 325:283-286(1961) [PubMed] [Europe PMC] [Abstract]
- "Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin."Nature 180:326-328(1957) [PubMed] [Europe PMC] [Abstract]
- "Isolation of a hemoglobin-derived opioid peptide from cerebrospinal fluid of patients with cerebrovascular bleedings."Biochem. Biophys. Res. Commun. 184:1060-1066(1992) [PubMed] [Europe PMC] [Abstract]
- "Hemoglobin Hammersmith (beta 42 (CD1) Phe replaced by Ser) associated with severe hemolytic anemia."Hemoglobin 5:97-105(1981) [PubMed&l