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Low Density Lipoprotein Receptor Related Protein 8 (LRP8)

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APOER2; Apolipoprotein E Receptor 2

Low Density Lipoprotein Receptor Related Protein 8 (LRP8)
CCC D099
HGNC 6700
MGI 1340044
PubMed 22589174
RGD 1305729
UniProt Q14114
Wiki LRP8
8is a member of the LDL receptor family that plays a role in endocytosis and signal transduction. Together with VLDLR it is able to bind reelin, leading to the phosphorylation of DAB1, which binds on its cytosolic tail.This gene encodes an apolipoprotein E receptor, a member of the low density lipoprotein receptor (LDLR) family. Apolipoprotein E is a small lipophilic plasma protein and a component of lipoproteins such as chylomicron remnants, very low density lipoprotein (VLDL), and high density lipoprotein (HDL). The apolipoprotein E receptor is involved in cellular recognition and internalization of these lipoproteins. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene.ApoER2 also regulates selenium intake into cells through endocytosis of SEPP1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD099Hu01 Recombinant Low Density Lipoprotein Receptor Related Protein 8 (LRP8) Positive Control; Immunogen; SDS-PAGE; WB.
RPD099Hu02 Recombinant Low Density Lipoprotein Receptor Related Protein 8 (LRP8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD099Hu01 Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 8 (LRP8) WB; IHC; ICC; IP.
Assay Kits SED099Hu ELISA Kit for Low Density Lipoprotein Receptor Related Protein 8 (LRP8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Low Density Lipoprotein Receptor Related Protein 8 (LRP8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Low Density Lipoprotein Receptor Related Protein 8 (LRP8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 8 (LRP8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Low Density Lipoprotein Receptor Related Protein 8 (LRP8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Low Density Lipoprotein Receptor Related Protein 8 (LRP8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD099Ra01 Recombinant Low Density Lipoprotein Receptor Related Protein 8 (LRP8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD099Ra01 Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 8 (LRP8) WB; IHC; ICC; IP.
MAD099Ra21 Monoclonal Antibody to Low Density Lipoprotein Receptor Related Protein 8 (LRP8) WB; IHC; ICC; IP.
Assay Kits SED099Ra ELISA Kit for Low Density Lipoprotein Receptor Related Protein 8 (LRP8) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain."J. Biol. Chem. 271:8373-8380(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene."J. Biol. Chem. 272:8498-8504(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of a novel exon in apolipoprotein E receptor 2 leading to alternatively spliced mRNAs found in cells of the vascular wall but not in neuronal tissue."J. Biol. Chem. 276:13192-13197(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Expression and alternate splicing of apolipoprotein E receptor 2 in brain."Neuroscience 90:903-911(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells."FEBS Lett. 540:181-187(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of LRP8 (apoER2) in human blood platelets."J. Lipid Res. 40:1925-1930(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Differential binding of ligands to the apolipoprotein E receptor 2."Biochemistry 42:9355-9364(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain."Biochemistry 42:10406-10417(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'."J. Biol. Chem. 278:33831-33838(2003) [PubMed] [Europe PMC] [Abstract]
  12. "The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2."J. Biol. Chem. 283:2363-2372(2008) [PubMed] [Europe PMC] [Abstract]
  13. "The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2."J. Biol. Chem. 285:19720-19726(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer's disease."Neurosci. Lett. 332:216-218(2002) [PubMed] [Europe PMC] [Abstract]
  15. "An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction." Am. J. Hum. Genet. 81:780-791(2007) [PubMed] [Europe PMC] [Abstract]