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Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)

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A2MRAP; A2RAP; HBP44; MRAP; RAP; Alpha-2-Macroglobulin Receptor-Associated Protein 1

Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)
CCC D100
HGNC 6701
MGI 96829
PubMed 14959998
RGD 620700
UniProt P30533
Wiki LRPAP1
LRPAP1 is involved with trafficking of certain members of the LDL receptor family including LRP1 and LRP2.The alpha-2-macroglobulin receptor complex, as purified by affinity chromatography, contains 3 polypeptides: a 515-kD heavy chain, an 85-kD light chain, and a 39-kD associated protein.The deduced amino acid sequence contains a putative signal sequence that precedes the 323-residue mature protein. The sequence showed 73% identity with a rat protein reported to be a pathogenic domain of the Heymann nephritis antigen gp330 and 77% identity to a 44-kD mouse heparin-binding protein termed HBP-44. There are also similarities between MRAP and apolipoprotein E. Studies indicated that the molecule is present on the cell surface, forming a complex with the heavy and light chains of the alpha-2-macroglobulin receptor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD100Hu01 Recombinant Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD100Hu01 Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD100Mu01 Recombinant Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPD100Mu02 Recombinant Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD100Mu01 Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1) WB; IHC; ICC; IP.
PAD100Mu02 Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1) WB; IHC; ICC; IP.
LAD100Mu71 Biotin-Linked Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD100Ra01 Recombinant Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD100Ra01 Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1) ELISA Kit Customized Service Offer
  1. "Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen."J. Biol. Chem. 266:13364-13369(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of the human LRPAP1 gene coding for the lipoprotein receptor-associated protein: identification of 22 polymorphisms and one mutation."Genomics 52:145-151(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein."Genomics 25:492-500(1995) [PubMed] [Europe PMC] [Abstract]
  6. "The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330."J. Biol. Chem. 267:21162-21166(1992) [PubMed] [Europe PMC] [Abstract]
  7. "39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein."EMBO J. 14:2269-2280(1995) [PubMed] [Europe PMC] [Abstract]
  8. "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein."J. Biol. Chem. 276:28889-28896(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in LRPAP1 are associated with severe myopia in humans."Am. J. Hum. Genet. 93:313-320(2013) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "The solution structure of the N-terminal domain of alpha2-macroglobulin receptor-associated protein."Proc. Natl. Acad. Sci. U.S.A. 94:7521-7525(1997) [PubMed] [Europe PMC] [Abstract]
  14. "1H, 13C and 15N resonance assignments of domain 1 of receptor associated protein."J. Biomol. NMR 26:187-188(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif."J. Mol. Biol. 362:700-716(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors."Mol. Cell 22:277-283(2006) [PubMed] [Europe PMC] [Abstract]
  17. "RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi."Mol. Cell 22:423-430(2006) [PubMed] [Europe PMC] [Abstract]