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Low Density Lipoprotein Receptor Related Protein 5 (LRP5)

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HBM; BMND1; EVR1; EVR4; LR3; LRP7; OPPG; OPS; OPTA1; VBCH2; Osteoporosis Pseudoglioma Syndrome; Exudative Vitreoretinopathy 1

Low Density Lipoprotein Receptor Related Protein 5 (LRP5)
CCC D102
HGNC 6697
MGI 1278315
PubMed 11719191
RGD 1309329
UniProt O75197
Wiki LRP5
LRP5 expression by osteoblasts in situ and showed that LRP5 can transduce Wnt signaling in vitro via the canonical pathway. They further showed that a mutant secreted form of Lrp5 could reduce bone thickness in mouse calvarial explant cultures. These data indicated that Wnt-mediated signaling via LRP5 affects bone accrual during growth and is important for the establishment of peak bone mass.LRP5 gene contains 23 coding exons and spans more than 100 kb. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD102Hu01 Recombinant Low Density Lipoprotein Receptor Related Protein 5 (LRP5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD102Hu01 Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 5 (LRP5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Low Density Lipoprotein Receptor Related Protein 5 (LRP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Low Density Lipoprotein Receptor Related Protein 5 (LRP5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Low Density Lipoprotein Receptor Related Protein 5 (LRP5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Low Density Lipoprotein Receptor Related Protein 5 (LRP5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 5 (LRP5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Low Density Lipoprotein Receptor Related Protein 5 (LRP5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Low Density Lipoprotein Receptor Related Protein 5 (LRP5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD102Ra01 Recombinant Low Density Lipoprotein Receptor Related Protein 5 (LRP5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD102Ra01 Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein 5 (LRP5) WB; IHC; ICC; IP.
MAD102Ra21 Monoclonal Antibody to Low Density Lipoprotein Receptor Related Protein 5 (LRP5) WB; IHC; ICC; IP.
Assay Kits SED102Ra ELISA Kit for Low Density Lipoprotein Receptor Related Protein 5 (LRP5) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity."Biochem. Biophys. Res. Commun. 251:784-790(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of a novel member of the low-density lipoprotein receptor family."Gene 216:103-111(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13."Genomics 72:231-242(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion." Proc. Natl. Acad. Sci. U.S.A. 100:229-234(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6."Curr. Biol. 11:951-961(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway."Mol. Cell 7:801-809(2001) [PubMed] [Europe PMC] [Abstract]
  9. "A mechanism for Wnt coreceptor activation."Mol. Cell 13:149-156(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd."Mol. Cell. Biol. 24:4677-4684(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling."J. Biol. Chem. 280:19883-19887(2005) [PubMed] [Europe PMC] [Abstract]
  12. "SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor."J. Biol. Chem. 280:26770-26775(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation."J. Biol. Chem. 281:12233-12241(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation."Biochemistry 46:6570-6577(2007) [PubMed] [Europe PMC] [Abstract]
  15. "A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V)."J. Cell. Biochem. 108:1066-1075(2009) [PubMed] [Europe PMC] [Abstract]
  16. "APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex."Nature 464:1043-1047(2010) [PubMed] [Europe PMC] [Abstract]
  17. "LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development." Cell 107:513-523(2001) [PubMed] [Europe PMC] [Abstract]
  18. "A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait." Am. J. Hum. Genet. 70:11-19(2002) [PubMed] [Europe PMC] [Abstract]
  19. "High bone density due to a mutation in LDL-receptor-related protein 5."N. Engl. J. Med. 346:1513-1521(2002) [PubMed] [Europe PMC] [Abstract]
  20. "Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density."Am. J. Hum. Genet. 72:763-771(2003) [PubMed] [Europe PMC] [Abstract]
  21. "Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q."Am. J. Hum. Genet. 74:721-730(2004) [PubMed] [Europe PMC] [Abstract]
  22. "Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites."Am. J. Hum. Genet. 74:866-875(2004) [PubMed] [Europe PMC] [Abstract]
  23. "Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5."Am. J. Hum. Genet. 75:878-884(2004) [PubMed] [Europe PMC] [Abstract]
  24. "LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density."J. Hum. Genet. 49:80-86(2004) [PubMed] [Europe PMC] [Abstract]
  25. "Clinical and molecular findings in osteoporosis-pseudoglioma syndrome."Am. J. Hum. Genet. 77:741-753(2005) [PubMed] [Europe PMC] [Abstract]
  26. "Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes."Hum. Mutat. 26:104-112(2005) [PubMed] [Europe PMC] [Abstract]
  27. "Heterozygous mutations in the LDL receptor-related protein 5 (LRP5) gene are associated with primary osteoporosis in children."J. Bone Miner. Res. 20:783-789(2005) [PubMed] [Europe PMC] [Abstract]
  28. "Oropharyngeal skeletal disease accompanying high bone mass and novel LRP5 mutation."J. Bone Miner. Res. 20:878-885(2005) [PubMed] [Europe PMC] [Abstract]
  29. "Missense mutations in LRP5 are not a common cause of idiopathic osteoporosis in adult men."J. Bone Miner. Res. 20:1951-1959(2005) [PubMed] [Europe PMC] [Abstract]
  30. "A family with osteoporosis pseudoglioma syndrome due to compound heterozygosity of two novel mutations in the LRP5 gene."Bone 39:470-476(2006) [PubMed] [Europe PMC] [Abstract]
  31. "Reduced bone mineral density and hyaloid vasculature remnants in a consanguineous recessive FEVR family with a mutation in LRP5."Br. J. Ophthalmol. 90:1163-1167(2006) [PubMed] [Europe PMC] [Abstract]
  32. "A novel mutation in the LRP5 gene is associated with osteoporosis-pseudoglioma syndrome."Osteoporos. Int. 18:1017-1018(2007) [PubMed] [Europe PMC] [Abstract]
  33. "Osteoporosis-pseudoglioma syndrome: description of 9 new cases and beneficial response to bisphosphonates."Bone 43:584-590(2008) [PubMed] [Europe PMC] [Abstract]
  34. "A mutation in the signal sequence of LRP5 in a family with an osteoporosis-pseudoglioma syndrome (OPPG)-like phenotype indicates a novel disease mechanism for trinucleotide repeats."Hum. Mutat. 30:641-648(2009) [PubMed] [Europe PMC] [Abstract]
  35. "Clinical and molecular evaluation of probands and family members with familial exudative vitreoretinopathy."Invest. Ophthalmol. Vis. Sci. 50:4379-4385(2009) [PubMed] [Europe PMC] [Abstract]
  36. "Overview of the mutation spectrum in familial exudative vitreoretinopathy and Norrie disease with identification of 21 novel variants in FZD4, LRP5, and NDP."Hum. Mutat. 31:656-666(2010) [PubMed] [Europe PMC] [Abstract]
  37. "Identification of two novel LRP5 mutations in families with familial exudative vitreoretinopathy."Mol. Vis. 20:395-409(2014) [PubMed] [Europe PMC] [Abstract]