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Stromal Interaction Molecule 2 (STIM2)

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Stromal Interaction Molecule 2 (STIM2)
CCC D109
HGNC 19205
MGI 2151156
PubMed 24698269
UniProt Q9P246
Wiki STIM2
Stromal Interaction Molecule 2 is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing.Flow cytometry and biotinylation studies showed that STIM2 was expressed intracellularly only, in contrast with the endoplasmic reticulum and plasma membrane expression of STIM1. Confocal microscopy demonstrated coexpression of STIM1 and STIM2 in puncta upon store depletion.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Stromal Interaction Molecule 2 (STIM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Stromal Interaction Molecule 2 (STIM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Stromal Interaction Molecule 2 (STIM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Stromal Interaction Molecule 2 (STIM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Stromal Interaction Molecule 2 (STIM2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Stromal Interaction Molecule 2 (STIM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Stromal Interaction Molecule 2 (STIM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Stromal Interaction Molecule 2 (STIM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Stromal Interaction Molecule 2 (STIM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Stromal Interaction Molecule 2 (STIM2) ELISA Kit Customized Service Offer
  1. "Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins."Biochem. J. 357:673-685(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx."Curr. Biol. 15:1235-1241(2005) [PubMed] [Europe PMC] [Abstract]
  7. "STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ entry."Curr. Biol. 16:1465-1470(2006) [PubMed] [Europe PMC] [Abstract]
  8. "STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels."Cell 131:1327-1339(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2."Biochem. Biophys. Res. Commun. 369:240-246(2008) [PubMed] [Europe PMC] [Abstract]
  10. "STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation."FASEB J. 22:752-761(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Stromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kinetics."J. Biol. Chem. 284:728-732(2009) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling."Cell 149:425-438(2012) [PubMed] [Europe PMC] [Abstract]
  15. "STIM2 drives Ca2+ oscillations through store-operated Ca2+ entry caused by mild store depletion."J. Physiol. (Lond.) 591:1433-1445(2013) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry."Proc. Natl. Acad. Sci. U.S.A. 108:1337-1342(2011) [PubMed] [Europe PMC] [Abstract]