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Antigen Peptide Transporter 1 (TAP1)

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APT1; ABC17; ABCB2; PSF1; RING4; Y3; TAP1N; Peptide Supply Factor 1; Atp-Binding Cassette,Subfamily B,Member 2; Peptide transporter involved in antigen processing 1

Antigen Peptide Transporter 1 (TAP1)
CCC D113
HGNC 43
MGI 98483
PubMed 1473153
RGD 3817
UniProt Q03518
Wiki TAP1
member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD113Hu01 Recombinant Antigen Peptide Transporter 1 (TAP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD113Hu01 Polyclonal Antibody to Antigen Peptide Transporter 1 (TAP1) WB; IHC; ICC; IP.
MAD113Hu21 Monoclonal Antibody to Antigen Peptide Transporter 1 (TAP1) WB; IHC; ICC; IP.
Assay Kits SED113Hu ELISA Kit for Antigen Peptide Transporter 1 (TAP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Antigen Peptide Transporter 1 (TAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Antigen Peptide Transporter 1 (TAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Antigen Peptide Transporter 1 (TAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Antigen Peptide Transporter 1 (TAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Antigen Peptide Transporter 1 (TAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Antigen Peptide Transporter 1 (TAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Antigen Peptide Transporter 1 (TAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Antigen Peptide Transporter 1 (TAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Antigen Peptide Transporter 1 (TAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Antigen Peptide Transporter 1 (TAP1) ELISA Kit Customized Service Offer
  1. "Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters."Nature 348:741-744(1990) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing."J. Mol. Biol. 228:433-441(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC."J. Mol. Biol. 255:1-13(1996) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility."Proc. Natl. Acad. Sci. U.S.A. 90:11079-11083(1993) [PubMed] [Europe PMC] [Abstract]
  7. "A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway."Nature 348:744-747(1990) [PubMed] [Europe PMC] [Abstract]
  8. "New allelic polymorphisms in TAP genes."Immunogenetics 39:374-374(1994) [PubMed] [Europe PMC] [Abstract]
  9. "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region."Proc. Natl. Acad. Sci. U.S.A. 88:10094-10098(1991) [PubMed] [Europe PMC] [Abstract]
  10. "A viral inhibitor of peptide transporters for antigen presentation."Nature 375:415-418(1995) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47."EMBO J. 15:3247-3255(1996) [PubMed] [Europe PMC] [Abstract]
  12. "Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site."J. Immunol. 157:5467-5477(1996) [PubMed] [Europe PMC] [Abstract]
  13. "Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10."Blood 90:2390-2397(1997) [PubMed] [Europe PMC] [Abstract]
  14. "The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP."Immunity 6:613-621(1997) [PubMed] [Europe PMC] [Abstract]
  15. "Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome."J. Clin. Invest. 103:755-758(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Adenovirus E19 has two mechanisms for affecting class I MHC expression."J. Immunol. 162:5049-5052(1999) [PubMed] [Europe PMC] [Abstract]
  17. "The human cytomegalovirus gene product US6 inhibits ATP binding by TAP."EMBO J. 20:387-396(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome."Mol. Immunol. 42:137-141(2005) [PubMed] [Europe PMC] [Abstract]
  19. "Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation."J. Immunol. 182:2313-2324(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing."EMBO J. 20:4964-4972(2001) [PubMed] [Europe PMC] [Abstract]
  22. "Allelic variants of the human putative peptide transporter involved in antigen processing."Proc. Natl. Acad. Sci. U.S.A. 89:3932-3936(1992) [PubMed] [Europe PMC] [Abstract]
  23. "A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer."Nat. Genet. 13:210-213(1996) [PubMed] [Europe PMC] [Abstract]
  24. "TAP1 polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies."Hum. Immunol. 62:256-268(2001) [PubMed] [Europe PMC] [Abstract]
  25. "Novel TAP1 polymorphisms in indigenous Zimbabweans: their potential implications on TAP function and in human diseases."Hum. Immunol. 64:823-829(2003) [PubMed] [Europe PMC] [Abstract]