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Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4)

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CHR-NB4; CHRN-B4; N-AChRB4; NAChRB4; N-AChR-B4; Neuronal Acetylcholine Receptor Beta 4

Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4)
CCC D145
HGNC 1964
MGI 87892
PubMed 22042774
RGD 2351
UniProt P30926
Wiki CHRNB4
The nAChRs are thought to be (hetero)pentamers composed of homologous subunits.Lou et al. reported a generalized MDR (GMDR) method that permitted adjustment for discrete and quantitative covariates and was applicable to both dichotomous and continuous phenotypes in population-based studies of various designs. They applied the method to a genetic study of 4 genes that were reported to be associated with nicotine dependence : CHRNA2, CHRNB4, BDNF, and NTRK2. They found significant joint action between CHRNB4 and NTRK2. Lou et al. commented that ubiquity of joint actions appears to be a natural property of complex inherited traits and that the term 'epistasis,' coined for a specific type of gene-by-gene interaction, has evolved to have different meanings in biologic and statistical genetics.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD145Hu01 Recombinant Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cholinergic Receptor, Nicotinic, Beta 4 (CHRNb4) ELISA Kit Customized Service Offer
  1. "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]
  2. "'Orphan' alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor."Mol. Pharmacol. 51:320-327(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."FEBS Lett. 400:309-314(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4."J. Hum. Genet. 46:362-366(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Transcription factors NF-Y and Sp1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta 4 subunit genes."J. Biol. Chem. 277:8866-8876(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines."FEBS Lett. 312:66-70(1992) [PubMed] [Europe PMC] [Abstract]
  9. "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."Mol. Pharmacol. 68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]