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Exoribonuclease 1 (ERI1)

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THEX1; 3'HEXO; 3'-5' exonuclease ERI1; Histone mRNA 3'-end-specific exoribonuclease; Enhanced RNAi Three Prime mRNA Exonuclease Homolog 1

Exoribonuclease 1 (ERI1)
CCC D162
HGNC 23994
MGI 1914526
PubMed 22613798
RGD 1308378
UniProt Q8IV48
Metazoan replication-dependent histone mRNAs end in a highly conserved stem-loop structure that is required for regulation of histone mRNA stability and is bound by stem loop-binding protein (SLBP). Using the histone mRNA stem-loop sequence in RNA affinity purification assays, Dominski et al. (2003) isolated HEXO (histone mRNA end-specific exonuclease) protein from HeLa whole-cell extracts. They sequenced regions of HEXO protein using mass spectrometry and matched this protein to a full-length protein from a sequence database. HEXO encodes a 50-kD protein containing a SAP domain capable of recognizing AT-rich scaffold-attachment regions (SARs) in chromosomal DNA, and a exonuclease domain similar to those of DEDD exonuclease family members.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD162Hu01 Recombinant Exoribonuclease 1 (ERI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD162Hu01 Polyclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Exoribonuclease 1 (ERI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exoribonuclease 1 (ERI1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD162Mu01 Recombinant Exoribonuclease 1 (ERI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD162Mu01 Polyclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Exoribonuclease 1 (ERI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exoribonuclease 1 (ERI1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Exoribonuclease 1 (ERI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Exoribonuclease 1 (ERI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Exoribonuclease 1 (ERI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Exoribonuclease 1 (ERI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Exoribonuclease 1 (ERI1) ELISA Kit Customized Service Offer
  1. "A 3' exonuclease that specifically interacts with the 3' end of histone mRNA."Mol. Cell 12:295-305(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans."Nature 427:645-649(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA."J. Biol. Chem. 281:30447-30454(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Crystallographic structure of the nuclease domain of 3'hExo, a DEDDh family member, bound to rAMP."J. Mol. Biol. 343:305-312(2004) [PubMed] [Europe PMC] [Abstract]