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Glucosidase Alpha, Neutral AB (GaNAB)

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GluII; G2AN; Alpha-glucosidase 2; Glucosidase II subunit alpha

Glucosidase Alpha, Neutral AB (GaNAB)
CCC D188
HGNC 4138
MGI 1097667
PubMed 21642380
RGD 1309775
UniProt Q14697
Wiki GANAB
Human tissues contain 2 isozymes of neutral alpha-glucosidase designated AB (GANAB) and C (GANC). Initially distinguished on the basis of differences in electrophoretic mobility in starch gel, the two have been shown to have other differences including those of substrate specificity. Since the AB form of mouse is not different electrophoretically from that in man, Martiniuk et al. used rocket immunoelectrophoresis to distinguish the enzymes from the 2 species.
Trombetta et al. (1996) isolated enzymatically active glucosidase II from rat liver and found that it was composed of 2 subunits, alpha and beta. Based on peptide sequences of the purified enzyme, they identified the corresponding human cDNAs in existing sequence databases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD188Hu01 Recombinant Glucosidase Alpha, Neutral AB (GaNAB) Positive Control; Immunogen; SDS-PAGE; WB.
APD188Hu01 Active Glucosidase Alpha, Neutral AB (GaNAB) Cell culture; Activity Assays.
Antibodies PAD188Hu01 Polyclonal Antibody to Glucosidase Alpha, Neutral AB (GaNAB) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glucosidase Alpha, Neutral AB (GaNAB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucosidase Alpha, Neutral AB (GaNAB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD188Mu01 Recombinant Glucosidase Alpha, Neutral AB (GaNAB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD188Mu01 Polyclonal Antibody to Glucosidase Alpha, Neutral AB (GaNAB) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glucosidase Alpha, Neutral AB (GaNAB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucosidase Alpha, Neutral AB (GaNAB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glucosidase Alpha, Neutral AB (GaNAB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glucosidase Alpha, Neutral AB (GaNAB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucosidase Alpha, Neutral AB (GaNAB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glucosidase Alpha, Neutral AB (GaNAB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucosidase Alpha, Neutral AB (GaNAB) ELISA Kit Customized Service Offer
  1. "The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo."Glycobiology 10:815-827(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (MAR-2007) to UniProtKB
  6. "Identity of neutral alpha-glucosidase AB and the glycoprotein processing enzyme glucosidase II. Biochemical and genetic studies."J. Biol. Chem. 260:1238-1242(1985) [PubMed] [Europe PMC] [Abstract]
  7. "Endoplasmic reticulum glucosidase II is composed of a catalytic subunit, conserved from yeast to mammals, and a tightly bound noncatalytic HDEL-containing subunit."J. Biol. Chem. 271:27509-27516(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]