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Ribonuclease A7 (RNASE7)

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SAP-2; Rnase-A7; Ribonuclease,RNase A Family 7; Skin-derived antimicrobial protein 2

Ribonuclease A7 (RNASE7)
CCC D193
HGNC 19278
PubMed 23302724
UniProt Q9H1E1
RNASE7 is a member of the RNase A superfamily that has broad-spectrum antimicrobial activity and ribonuclease activity .Harder and Schroder showed that recombinant RNASE7 displayed catalytic activity against yeast tRNA. They found that RNASE7 exhibited broad-spectrum antimicrobial activity against several gram-positive and gram-negative bacteria, and against Candida albicans, as well as vancomycin-resistant E. faecium. RNASE7 expression was induced upon treatment with interferon gamma, interleukin-1-beta, and to a lesser extent by TNF-alpha. Zhang et al. also identified broad spectrum RNASE7 antimicrobial activity. However, they determined that RNASE7 did not display antiviral activity against respiratory syncytial virus infectivity for human epithelium cells using an in vitro assay. They confirmed that recombinant RNASE7 displayed catalytic activity against yeast tRNA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD193Hu01 Recombinant Ribonuclease A7 (RNASE7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD193Hu01 Polyclonal Antibody to Ribonuclease A7 (RNASE7) WB
LAD193Hu71 Biotin-Linked Polyclonal Antibody to Ribonuclease A7 (RNASE7) WB; IHC; ICC.
MAD193Hu21 Monoclonal Antibody to Ribonuclease A7 (RNASE7) WB; IHC; ICC; IP.
Assay Kits SED193Hu ELISA Kit for Ribonuclease A7 (RNASE7) Enzyme-linked immunosorbent assay for Antigen Detection.
HED193Hu High Sensitive ELISA Kit for Ribonuclease A7 (RNASE7) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin."J. Biol. Chem. 277:46779-46784(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Human RNase 7: a new cationic ribonuclease of the RNase A superfamily."Nucleic Acids Res. 31:602-607(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (MAR-1997) to UniProtKB
  7. "The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity."J. Biol. Chem. 282:4626-4633(2007) [PubMed] [Europe PMC] [Abstract]