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Troponin C Type 1, Slow (TNNC1)

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TNC; TroponinC, Cardiac; Troponin C, slow skeletal and cardiac muscles

Troponin C Type 1, Slow (TNNC1)
CCC D227
HGNC 11943
MGI 98779
PubMed 22815480
RGD 1309921
UniProt P63316
Wiki TNNC1
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z.Using a human/rodent monochromosomal mapping panel, Song et al. (1996) mapped a human symbolized TNNC1 to chromosome 3 by PCR. Chromosome 3 somatic cell hybrids with various rearrangements were used for finer mapping to 3p21.3-p14.3.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD227Hu01 Recombinant Troponin C Type 1, Slow (TNNC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD227Hu01 Polyclonal Antibody to Troponin C Type 1, Slow (TNNC1) WB; IHC; ICC; IP.
MAD227Hu21 Monoclonal Antibody to Troponin C Type 1, Slow (TNNC1) WB
Assay Kits SED227Hu ELISA Kit for Troponin C Type 1, Slow (TNNC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Troponin C Type 1, Slow (TNNC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Troponin C Type 1, Slow (TNNC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Troponin C Type 1, Slow (TNNC1) Polyclonal Antibody Customized Service Offer
Assay Kits SED227Mu ELISA Kit for Troponin C Type 1, Slow (TNNC1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Troponin C Type 1, Slow (TNNC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Troponin C Type 1, Slow (TNNC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Troponin C Type 1, Slow (TNNC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Troponin C Type 1, Slow (TNNC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Troponin C Type 1, Slow (TNNC1) ELISA Kit Customized Service Offer
  1. "The amino acid sequence of human cardiac troponin-C."Muscle Nerve 9:73-77(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts."J. Mol. Biol. 201:379-391(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning, structural analysis, and expression of the human slow twitch skeletal muscle/cardiac troponin C gene."J. Biol. Chem. 265:21247-21253(1990) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Calcium-induced structural transition in the regulatory domain of human cardiac troponin C."Biochemistry 36:12138-12146(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Structural and functional domains of the troponin complex revealed by limited digestion."Eur. J. Biochem. 246:611-617(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Structure and dynamics of the C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I."J. Biol. Chem. 278:27024-27034(2003) [PubMed] [Europe PMC] [Abstract]
  8. "First mutation in cardiac troponin C, L29Q, in a patient with hypertrophic cardiomyopathy."Hum. Mutat. 17:524-524(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy."J. Am. Coll. Cardiol. 44:2033-2040(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Cardiac troponin C-L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C."FEBS J. 272:6087-6097(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C."J. Mol. Cell. Cardiol. 45:281-288(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy."J. Biol. Chem. 284:19090-19100(2009) [PubMed] [Europe PMC] [Abstract]