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Keratin 6A (KRT6A)

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K6A; KRT6C; KRT6D; CK6C; K6C; CK6D; K6D; Keratin 6C; Keratin 6D; Keratin, type II cytoskeletal 6A; Type-II keratin Kb6

Keratin 6A (KRT6A)
CCC D234
HGNC 6443
MGI 1100845
PubMed 22098151
UniProt P02538
Wiki Keratin_6A

Keratin 6A is a type II cytokeratin, one of a number of isoforms of keratin 6 encoded by separate genes located within the type II keratin gene cluster on human chromosome 12q. It is found with keratin 16 and/or keratin 17 in the palm and sole epidermis, the epithelial cells of the nail bed, the filiform papillae of the tongue, the epithelial lining of oral mucosa and esophagus, as well as the hair follicles. This keratin 6 isoform is thought to be the most abundant of the K6 isoforms.

The KRT6A gene consists of 9 exons separated by 8 introns and is located in the type II keratin gene cluster on human chromosome 12q. Keratin 6B and keratin 6C are encoded by the neighbouring genes, which are identical in intron-exon organization to KRT6A and are more than 99% identical in their DNA coding sequences.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD234Hu01 Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD234Hu01 Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
LAD234Hu71 Biotin-Linked Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC.
LAD234Hu81 FITC-Linked Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IF.
MAD234Hu21 Monoclonal Antibody to Keratin 6A (KRT6A) WB
Assay Kits SED234Hu ELISA Kit for Keratin 6A (KRT6A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Keratin 6A (KRT6A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Keratin 6A (KRT6A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Keratin 6A (KRT6A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Keratin 6A (KRT6A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Keratin 6A (KRT6A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD234Ra01 Recombinant Keratin 6A (KRT6A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD234Ra01 Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC; IP.
LAD234Ra71 Biotin-Linked Polyclonal Antibody to Keratin 6A (KRT6A) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Keratin 6A (KRT6A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Keratin 6A (KRT6A) ELISA Kit Customized Service Offer
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  3. , Submitted (MAR-2008) to UniProtKB
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  12. "[A de nono I462S mutation in the KRT6A gene is associated with pachyonychia congenita type I]."Zhonghua Yi Xue Za Zhi 84:1344-1347(2004) [PubMed] [Europe PMC] [Abstract]
  13. "A severe case of pachyonychia congenita type I due to a novel proline mutation in keratin 6a."Br. J. Dermatol. 152:800-802(2005) [PubMed] [Europe PMC] [Abstract]
  14. "The genetic basis of pachyonychia congenita."J. Investig. Dermatol. Symp. Proc. 10:21-30(2005) [PubMed] [Europe PMC] [Abstract]
  15. "A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita."J. Dermatol. Sci. 48:199-205(2007) [PubMed] [Europe PMC] [Abstract]
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  17. "Mutations of KRT6A are more frequent than those of KRT16 in pachyonychia congenita type 1: report of a novel and a recently reported mutation in two unrelated Chinese families."Br. J. Dermatol. 159:238-240(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Novel and recurrent keratin 6A (KRT6A) mutations in Chinese patients with pachyonychia congenita type 1."Br. J. Dermatol. 160:1327-1329(2009) [PubMed] [Europe PMC] [Abstract]
  19. "A large mutational study in pachyonychia congenita."J. Invest. Dermatol. 131:1018-1024(2011) [PubMed] [Europe PMC] [Abstract]