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G Protein Coupled Receptor Kinase 5 (GRK5)

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GPRK5; G protein-coupled receptor kinase GRK5

G Protein Coupled Receptor Kinase 5 (GRK5)
CCC D254
HGNC 4544
MGI 109161
PubMed 18425130
RGD 61985
UniProt P34947
Wiki GRK5
G protein-coupled receptor kinase 5 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).
Bullrich et al. (1995) used a rodent-human hybrid panel to map 2 newly identified members of the GRK family: GPRK5 and GPRK6 to 10q24-qter and 5q35, respectively. The hybrid cells containing parts of chromosomes 10 and 5 were used for the regionalization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD254Hu01 Recombinant G Protein Coupled Receptor Kinase 5 (GRK5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD254Hu01 Polyclonal Antibody to G Protein Coupled Receptor Kinase 5 (GRK5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor Kinase 5 (GRK5) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor Kinase 5 (GRK5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor Kinase 5 (GRK5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor Kinase 5 (GRK5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor Kinase 5 (GRK5) Polyclonal Antibody Customized Service Offer
Assay Kits SED254Mu ELISA Kit for G Protein Coupled Receptor Kinase 5 (GRK5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor Kinase 5 (GRK5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor Kinase 5 (GRK5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor Kinase 5 (GRK5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor Kinase 5 (GRK5) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor Kinase 5 (GRK5) ELISA Kit Customized Service Offer
  1. "Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family."Proc. Natl. Acad. Sci. U.S.A. 90:5588-5592(1993) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart."Circulation 87:454-463(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5."J. Biol. Chem. 269:10209-10212(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Regulation of G protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain."J. Biol. Chem. 272:18273-18280(1997) [PubMed] [Europe PMC] [Abstract]
  7. "A predicted amphipathic helix mediates plasma membrane localization of GRK5."J. Biol. Chem. 279:17989-17995(2004) [PubMed] [Europe PMC] [Abstract]
  8. "G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence."Mol. Cell. Biol. 24:10169-10179(2004) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling."EMBO J. 28:2706-2718(2009) [PubMed] [Europe PMC] [Abstract]
  11. "G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway."J. Biol. Chem. 284:35040-35048(2009) [PubMed] [Europe PMC] [Abstract]
  12. "G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis."J. Biol. Chem. 285:12823-12830(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation."Mol. Pharmacol. 77:405-415(2010) [PubMed] [Europe PMC] [Abstract]
  14. "G protein-coupled receptor kinase 5 phosphorylation of Hip regulates internalization of the chemokine receptor CXCR4."Biochemistry 50:6933-6941(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  16. "A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure."Nat. Med. 14:510-517(2008) [PubMed] [Europe PMC] [Abstract]