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G Protein Coupled Receptor 3 (GPR3)

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ACCA; ACCA orphan receptor

G Protein Coupled Receptor 3 (GPR3)
CCC D260
HGNC 4484
MGI 101908
PubMed 15591206
RGD 628686
UniProt P46089
Wiki GPR3
Marchese et al. (1994) cloned a gene designated GPR3 that showed 56% identity in the transmembrane regions with a previously characterized cDNA clone from rat.
G-protein coupled receptor 3 isa member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.GPR3 activates adenylate cyclase in the absence of ligand. GPR3 is expressed in mammalian oocytes where it maintains meiotic arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue. While GPR3 have a certain level of constitutive activity, it is believed that sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are ligands that further activate the receptor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor 3 (GPR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 3 (GPR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 3 (GPR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 3 (GPR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 3 (GPR3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor 3 (GPR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 3 (GPR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 3 (GPR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 3 (GPR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 3 (GPR3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant G Protein Coupled Receptor 3 (GPR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to G Protein Coupled Receptor 3 (GPR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to G Protein Coupled Receptor 3 (GPR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for G Protein Coupled Receptor 3 (GPR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for G Protein Coupled Receptor 3 (GPR3) ELISA Kit Customized Service Offer
  1. "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors."Genomics 28:347-349(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system."Genomics 24:391-394(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase."Biochem. J. 309:837-843(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning of human genes encoding novel G protein-coupled receptors."Genomics 23:609-618(1994) [PubMed] [Europe PMC] [Abstract]
  8. "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors."Cell. Signal. 14:941-953(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay."J. Biol. Chem. 284:12328-12338(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons."Science 323:946-951(2009) [PubMed] [Europe PMC] [Abstract]