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Cyclin C (CCNC)

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CCN-C; CycC; hSRB11; SRB11 homolog

Cyclin C (CCNC)
CCC D267
HGNC 1581
MGI 1858199
PubMed 19967789
RGD 70905
UniProt P24863
Wiki Cyclin_C
Cyclin-C is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin C (CCNC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin C (CCNC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin C (CCNC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin C (CCNC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin C (CCNC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin C (CCNC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin C (CCNC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin C (CCNC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin C (CCNC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin C (CCNC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin C (CCNC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin C (CCNC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin C (CCNC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin C (CCNC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin C (CCNC) ELISA Kit Customized Service Offer
  1. "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast."Cell 66:1197-1206(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors."Genomics 32:253-259(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II."Oncogene 12:2631-2640(1996) [PubMed] [Europe PMC] [Abstract]
  6. "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription."Mol. Cell 2:213-222(1998) [PubMed] [Europe PMC] [Abstract]
  7. "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation."Mol. Cell 3:97-108(1999) [PubMed] [Europe PMC] [Abstract]
  8. ErratumMol. Cell 3:541-541(1999)
  9. "TFIIH is negatively regulated by cdk8-containing mediator complexes."Nature 407:102-106(2000) [PubMed] [Europe PMC] [Abstract]
  10. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly."J. Biol. Chem. 281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract]
  12. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  14. "The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder."J. Mol. Biol. 412:251-266(2011) [PubMed] [Europe PMC] [Abstract]