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Cyclin Y (CCNY)

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CCN-Y; CFP1; CBCP1; Cyclin box protein 1; Cyclin fold protein 1; cyclin-X

Cyclin Y (CCNY)
CCC D270
HGNC 23354
MGI 1915224
PubMed 20699655
RGD 1565969
UniProt Q8ND76
Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases By database analysis and PCR of a testis cDNA library.The deduced 287-amino acid protein has a central cyclin box and shares highest similarity with cyclin B3 (CCNB3). RT-PCR detected highest expression in testis and lower expression in all other tissues examined except brain and kidney. Fluorescence-tagged CCNX was expressed predominantly in the nucleus in a human nonsmall lung cancer cell line.Using mass spectrometry to identify proteins upregulated in metastatic versus nonmetastatic human colorectal adenocarcinoma cell lines, followed by database analysis, Zhang et al. (2005) identified an isoform of CCNY that they called CFP1 variant A. The deduced protein has a calculated molecular mass of 36.9 kD.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD270Hu01 Recombinant Cyclin Y (CCNY) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD270Hu01 Polyclonal Antibody to Cyclin Y (CCNY) WB; IHC; ICC; IP.
MAD270Hu21 Monoclonal Antibody to Cyclin Y (CCNY) WB; IHC; ICC; IP.
Assay Kits SED270Hu ELISA Kit for Cyclin Y (CCNY) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Y (CCNY) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Y (CCNY) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Y (CCNY) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin Y (CCNY) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Y (CCNY) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Y (CCNY) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Y (CCNY) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Y (CCNY) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin Y (CCNY) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Y (CCNY) ELISA Kit Customized Service Offer
  1. "Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1."FEBS Lett. 583:2171-2178(2009) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of cyclin X which activates transcriptional activities of c-Myc."Mol. Biol. Rep. 36:97-103(2009) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Cell cycle control of wnt receptor activation."Dev. Cell 17:788-799(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis."Mol. Cell. Biol. 32:868-879(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation."FEBS Lett. 588:1989-1996(2014) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]