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Cyclin T (CCNT)

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CCNT1; CCN-T; CYCT1; HIVE1; Cyclin T1; Human Immunodeficiency Virus Type 1(HIV-1)Expression(Elevated)

Cyclin T (CCNT)
CCC D271
HGNC 1599
MGI 1328363
PubMed 12494448
RGD 1311151
UniProt O60563
Wiki Cyclin_T1
Cyclin-T1 is a protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle.
This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin T (CCNT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin T (CCNT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin T (CCNT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin T (CCNT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin T (CCNT) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin T (CCNT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin T (CCNT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin T (CCNT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin T (CCNT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin T (CCNT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin T (CCNT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin T (CCNT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin T (CCNT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin T (CCNT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin T (CCNT) ELISA Kit Customized Service Offer
  1. "A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA."Cell 92:451-462(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of multiple cyclin subunits of human P-TEFb."Genes Dev. 12:755-762(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription."EMBO J. 18:3688-3701(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation."J. Mol. Biol. 288:41-56(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Role of the human and murine cyclin T proteins in regulating HIV-1 Tat-activation."J. Mol. Biol. 288:57-69(1999) [PubMed] [Europe PMC] [Abstract]
  7. "The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein."Genes Dev. 12:3512-3527(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes."J. Virol. 73:5777-5786(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter."Mol. Cell. Biol. 20:5897-5907(2000) [PubMed] [Europe PMC] [Abstract]
  10. "MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein."J. Biomed. Sci. 9:234-245(2002) [PubMed] [Europe PMC] [Abstract]
  11. "The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription."Mol. Cell. Biol. 23:6373-6384(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Evidence for conformational flexibility in the Tat-TAR recognition motif of cyclin T1."Virology 318:306-317(2004) [PubMed] [Europe PMC] [Abstract]
  13. "The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription."Mol. Cell 19:523-534(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4."Mol. Cell 19:535-545(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme."Mol. Cell 27:262-274(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]