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Cyclin T2 (CCNT2)

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CCN-T2; CycT2

Cyclin T2 (CCNT2)
CCC D272
HGNC 1600
MGI 1920199
PubMed 16245309
RGD 1309205
UniProt O60583
Wiki Cyclin_T2
Cyclin-T2 is a protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event.
This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. Two alternatively spliced transcript variants, which encode distinct isoforms, have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin T2 (CCNT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin T2 (CCNT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin T2 (CCNT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin T2 (CCNT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin T2 (CCNT2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin T2 (CCNT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin T2 (CCNT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin T2 (CCNT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin T2 (CCNT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin T2 (CCNT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin T2 (CCNT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin T2 (CCNT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin T2 (CCNT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin T2 (CCNT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin T2 (CCNT2) ELISA Kit Customized Service Offer
  1. "Identification of multiple cyclin subunits of human P-TEFb."Genes Dev. 12:755-762(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes."J. Virol. 73:5777-5786(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]