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Cyclin L2 (CCNL2)

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CCN-L2; ANIA-6B; HCLA-ISO; HLA-ISO; PCEE; SB138; CCNM; Cyclin M; Paneth cell-enhanced expression protein

Cyclin L2 (CCNL2)
CCC D275
HGNC 20570
MGI 1927119
PubMed 22799343
UniProt Q96S94
Wiki CCNL2
Cyclin L2 contains an N-terminal cyclin domain and a C-terminal arginine/serine-rich domain (RS domain), which is a hallmark of many proteins involved in pre-mRNA processing. The gene for cyclin L2 encodes the full-length cyclin L2, which is predominantly expressed in testis, as well as a truncated splicing variant (cyclin L2S) that lacks the RS domain and is ubiquitously expressed in human tissues. Full-length cyclin L2, but not cyclin L2S, was associated with the cyclin-dependent kinase PITSLRE.
Cyclin L2 interacted with splicing factor 2 in vitro and was co-localized with the splicing factor SC35 in the nuclear speckle compartment. In striking contrast, the closely related green fluorescent protein-cyclin L1 was immobile in the speckle compartment.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin L2 (CCNL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin L2 (CCNL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin L2 (CCNL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin L2 (CCNL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin L2 (CCNL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin L2 (CCNL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin L2 (CCNL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin L2 (CCNL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin L2 (CCNL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin L2 (CCNL2) ELISA Kit Customized Service Offer
  1. "Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells."J. Biol. Chem. 279:11639-11648(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]