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Cytochrome P450 1A2 (CYP1A2)

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CP12; P3-450; P450(PA); Cytochrome P450,Family 1,Subfamily A,Polypeptide 2

Cytochrome P450 1A2 (CYP1A2)
CCC D294
HGNC 2596
MGI 88589
PubMed 18398030
RGD 2459
UniProt P05177
Wiki CYP1A2
Cytochrome P450 1A2 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD294Hu01 Recombinant Cytochrome P450 1A2 (CYP1A2) Positive Control; Immunogen; SDS-PAGE; WB.
RPD294Hu02 Recombinant Cytochrome P450 1A2 (CYP1A2) Positive Control; Immunogen; SDS-PAGE; WB.
APD294Hu01 Active Cytochrome P450 1A2 (CYP1A2) Cell culture; Activity Assays.
CPD294Hu21 OVA Conjugated Cytochrome P450 1A2 (CYP1A2) Immunogen; SDS-PAGE; WB.
Antibodies PAD294Hu01 Polyclonal Antibody to Cytochrome P450 1A2 (CYP1A2) WB; IHC; ICC; IP.
PAD294Hu02 Polyclonal Antibody to Cytochrome P450 1A2 (CYP1A2) WB; IHC; ICC; IP.
LAD294Hu71 Biotin-Linked Polyclonal Antibody to Cytochrome P450 1A2 (CYP1A2) WB; IHC; ICC.
PAD294Hu08 Polyclonal Antibody to Cytochrome P450 1A2 (CYP1A2) WB; IHC; ICC; IP.
Assay Kits SED294Hu ELISA Kit for Cytochrome P450 1A2 (CYP1A2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 1A2 (CYP1A2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 1A2 (CYP1A2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 1A2 (CYP1A2) Polyclonal Antibody Customized Service Offer
Assay Kits SED294Mu ELISA Kit for Cytochrome P450 1A2 (CYP1A2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD294Ra01 Recombinant Cytochrome P450 1A2 (CYP1A2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD294Ra01 Polyclonal Antibody to Cytochrome P450 1A2 (CYP1A2) WB; IHC; ICC; IP.
MAD294Ra21 Monoclonal Antibody to Cytochrome P450 1A2 (CYP1A2) WB; IHC; ICC; IP.
Assay Kits SED294Ra ELISA Kit for Cytochrome P450 1A2 (CYP1A2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human P3(450): cDNA and complete amino acid sequence."Nucleic Acids Res. 14:6773-6774(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA."Proc. Natl. Acad. Sci. U.S.A. 83:6731-6735(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression."Mol. Endocrinol. 3:1399-1408(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15."J. Exp. Pathol. 3:1-17(1987) [PubMed] [Europe PMC] [Abstract]
  5. "Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation."Pharmacogenetics 11:1-6(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat."Mol. Pharmacol. 29:405-410(1986) [PubMed] [Europe PMC] [Abstract]
  8. "Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6."DNA 4:395-400(1985) [PubMed] [Europe PMC] [Abstract]
  9. "Functional characterization of four allelic variants of human cytochrome P450 1A2."Arch. Biochem. Biophys. 422:23-30(2004) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2."J. Biol. Chem. 282:14348-14355(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese."Drug Metab. Dispos. 27:98-101(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Five novel natural allelic variants-951A->C, 1042G->A (D348N), 1156A->T (I386F), 1217G->A (C406Y) and 1291C->T (C431Y)-of the human CYP1A2 gene in a French Caucasian population."Hum. Mutat. 17:355-356(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes."J. Pharmacol. Exp. Ther. 308:300-306(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population." Drug Metab. Pharmacokinet. 20:24-33(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus."Hum. Mutat. 25:196-206(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Coffee, CYP1A2 genotype, and risk of myocardial infarction."JAMA 295:1135-1141(2006) [PubMed] [Europe PMC] [Abstract]