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Cytochrome P450 1B1 (CYP1B1)

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CP1B; GLC3A; Cytochrome P450,Family 1,Subfamily B,Polypeptide 1; Glaucoma 3,Primary Infantile

Cytochrome P450 1B1 (CYP1B1)
CCC D297
HGNC 2597
MGI 88590
PubMed 11264459
RGD 2460
UniProt Q16678
Wiki CYP1B1
CYP1B1 a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.CYP1A1 and CYP1B1 are regulated by the Aryl hydrocarbon receptor, a ligand activated transcription factor. They are part of the Phase I reactions in drug metabolism.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD297Hu01 Recombinant Cytochrome P450 1B1 (CYP1B1) Positive Control; Immunogen; SDS-PAGE; WB.
APD297Hu01 Active Cytochrome P450 1B1 (CYP1B1) Cell culture; Activity Assays.
Antibodies PAD297Hu01 Polyclonal Antibody to Cytochrome P450 1B1 (CYP1B1) WB; IHC; ICC; IP.
LAD297Hu71 Biotin-Linked Polyclonal Antibody to Cytochrome P450 1B1 (CYP1B1) WB; IHC; ICC.
MAD297Hu21 Monoclonal Antibody to Cytochrome P450 1B1 (CYP1B1) WB; IHC; ICC; IP.
Assay Kits SED297Hu ELISA Kit for Cytochrome P450 1B1 (CYP1B1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 1B1 (CYP1B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 1B1 (CYP1B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 1B1 (CYP1B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 1B1 (CYP1B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 1B1 (CYP1B1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 1B1 (CYP1B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 1B1 (CYP1B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 1B1 (CYP1B1) Polyclonal Antibody Customized Service Offer
Assay Kits SED297Ra ELISA Kit for Cytochrome P450 1B1 (CYP1B1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  8. "Specificity determinants of CYP1B1 estradiol hydroxylation."Mol. Pharmacol. 84:451-458(2013) [PubMed] [Europe PMC] [Abstract]
  9. "The citrus flavanone naringenin suppresses CYP1B1 transactivation through antagonising xenobiotic-responsive element binding."Br. J. Nutr. 109:1598-1605(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Structural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1."J. Biol. Chem. 286:5736-5743(2011) [PubMed] [Europe PMC] [Abstract]
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  12. "Sequence analysis and homology modeling suggest that primary congenital glaucoma on 2p21 results from mutations disrupting either the hinge region or the conserved core structures of cytochrome P4501B1."Am. J. Hum. Genet. 62:573-584(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Association of cytochrome P450 1B1 (CYP1B1) polymorphism with steroid receptor status in breast cancer."Cancer Res. 58:5038-5041(1998) [PubMed] [Europe PMC] [Abstract]
  14. ErratumCancer Res. 59:1388-1388(1999)
  15. "Identification of a single ancestral CYP1B1 mutation in Slovak Gypsies (Roms) affected with primary congenital glaucoma."J. Med. Genet. 36:290-294(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Multiple CYP1B1 mutations and incomplete penetrance in an inbred population segregating primary congenital glaucoma suggest frequent de novo events and a dominant modifier locus."Hum. Mol. Genet. 9:367-374(2000) [PubMed] [Europe PMC] [Abstract]
  17. ErratumHum. Mol. Genet. 9:1141-1141(2000)
  18. "Novel compound heterozygous mutations in the cytochrome P4501B1 gene (CYP1B1) in a Japanese patient with primary congenital glaucoma."Ophthalmic Genet. 21:191-193(2000) [PubMed] [Europe PMC] [Abstract]
  19. "Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer."Pharmacogenetics 10:25-33(2000) [PubMed] [Europe PMC] [Abstract]
  20. "Novel cytochrome P4501B1 (CYP1B1) gene mutations in Japanese patients with primary congenital glaucoma."Invest. Ophthalmol. Vis. Sci. 42:2211-2216(2001) [PubMed] [Europe PMC] [Abstract]
  21. ErratumInvest. Ophthalmol. Vis. Sci. 42:2775-2775(2001)
  22. "Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene."Am. J. Hum. Genet. 70:448-460(2002) [PubMed] [Europe PMC] [Abstract]
  23. "Identification of novel mutations causing familial primary congenital glaucoma in Indian pedigrees."Invest. Ophthalmol. Vis. Sci. 43:1358-1366(2002) [PubMed] [Europe PMC] [Abstract]
  24. "Molecular genetics of primary congenital glaucoma in Brazil."Invest. Ophthalmol. Vis. Sci. 43:1820-1827(2002) [PubMed] [Europe PMC] [Abstract]
  25. "Functional analysis of six different polymorphic CYP1B1 enzyme variants found in an Ethiopian population."Mol. Pharmacol. 61:586-594(2002) [PubMed] [Europe PMC] [Abstract]
  26. "Gene symbol: CYP1B1. Disease: glaucoma, primary congenital."Hum. Genet. 113:556-558(2003) [PubMed] [Europe PMC] [Abstract]
  27. "Novel cytochrome P450 1B1 (CYP1B1) mutations in patients with primary congenital glaucoma in France."Hum. Mutat. 22:496-496(2003) [PubMed] [Europe PMC] [Abstract]
  28. "CYP1B1 gene analysis in primary congenital glaucoma in Indonesian and European patients."J. Med. Genet. 40:E9-E9(2003) [PubMed] [Europe PMC] [Abstract]
  29. "CYP1B1 mutations in French patients with early-onset primary open-angle glaucoma."J. Med. Genet. 41:647-651(2004) [PubMed] [Europe PMC] [Abstract]
  30. "Mutation spectrum of the CYP1B1 gene in Indian primary congenital glaucoma patients."Mol. Vis. 10:696-702(2004) [PubMed] [Europe PMC] [Abstract]
  31. "Cytochrome P4501B1 mutations cause only part of primary congenital glaucoma in Ecuador."Ophthalmic Genet. 25:3-9(2004) [PubMed] [Europe PMC] [Abstract]
  32. "Molecular and clinical evaluation of primary congenital glaucoma in Kuwait."Am. J. Ophthalmol. 141:512-516(2006) [PubMed] [Europe PMC] [Abstract]
  33. "Primary role of CYP1B1 in Indian juvenile-onset POAG patients."Mol. Vis. 12:399-404(2006) [PubMed] [Europe PMC] [Abstract]
  34. "Primary congenital glaucoma and Rieger's anomaly: extended haplotypes reveal founder effects for eight distinct CYP1B1 mutations."Mol. Vis. 12:523-531(2006) [PubMed] [Europe PMC] [Abstract]
  35. "Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma."Mol. Vis. 12:748-755(2006) [PubMed] [Europe PMC] [Abstract]
  36. "Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme."Hum. Mutat. 29:1147-1153(2008) [PubMed] [Europe PMC] [Abstract]