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Cytochrome P450 3A4 (CYP3A4)

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CYP3A3; CYPIIIA4; 1,8-cineole 2-exo-monooxygenase; Albendazole sulfoxidase; Nifedipine oxidase; Quinine 3-monooxygenase; Taurochenodeoxycholate 6-alpha-hydroxylase

Cytochrome P450 3A4 (CYP3A4)
CCC D299
HGNC 2637
MGI 88609
PubMed 20697309
UniProt P08684
Wiki CYP3A4
CYP3A4is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD299Hu01 Recombinant Cytochrome P450 3A4 (CYP3A4) Positive Control; Immunogen; SDS-PAGE; WB.
APD299Hu01 Active Cytochrome P450 3A4 (CYP3A4) Cell culture; Activity Assays.
Antibodies PAD299Hu01 Polyclonal Antibody to Cytochrome P450 3A4 (CYP3A4) WB; IHC; ICC; IP.
MAD299Hu21 Monoclonal Antibody to Cytochrome P450 3A4 (CYP3A4) WB; IHC; ICC; IP.
Assay Kits SED299Hu ELISA Kit for Cytochrome P450 3A4 (CYP3A4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD299Mu01 Recombinant Cytochrome P450 3A4 (CYP3A4) Positive Control; Immunogen; SDS-PAGE; WB.
RPD299Mu02 Recombinant Cytochrome P450 3A4 (CYP3A4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD299Mu01 Polyclonal Antibody to Cytochrome P450 3A4 (CYP3A4) WB; IHC; ICC; IP.
PAD299Mu02 Polyclonal Antibody to Cytochrome P450 3A4 (CYP3A4) WB; IHC; ICC; IP.
Assay Kits SED299Mu ELISA Kit for Cytochrome P450 3A4 (CYP3A4) Enzyme-linked immunosorbent assay for Antigen Detection.
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  20. "CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases."Arch. Biochem. Biophys. 483:66-74(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function."Drug Metab. Dispos. 37:1528-1538(2009) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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  26. "Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos."J. Pharmacol. Exp. Ther. 299:825-831(2001) [PubMed] [Europe PMC] [Abstract]
  27. "Identification and functional characterization of eight CYP3A4 protein variants."Pharmacogenetics 11:447-458(2001) [PubMed] [Europe PMC] [Abstract]
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