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Cytochrome P450 2B6 (CYP2B6)

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CYP2B; CPB6; CYPIIB6; Cytochrome P450,Subfamily IIB(Phenobarbital-Inducible)Polypeptide 6; 1,4-cineole 2-exo-monooxygenase; Cytochrome P450 IIB1

Cytochrome P450 2B6 (CYP2B6)
CCC D300
HGNC 2615
MGI 88598
PubMed 14977870
UniProt P20813
Wiki CYP2B6
Miles et al. (1988) reported the isolation of cDNA clones that seemed, on the basis of their sequence homology to the rat P450IIB1 cDNA, to be encoded by part of the human P450IIB subfamily. Evidence of alternative splicing at the CYP2B locus was presented. Yamano et al. (1989) demonstrated 2 anomalous cDNAs derived from the CYP2B locus on chromosome 19. Thum and Borlak (2000) investigated the gene expression of major human cytochrome P450 genes in various regions of explanted hearts from 6 patients with dilated cardiomyopathy and 1 with transposition of the arterial trunk and 2 samples of normal heart. mRNA for cytochrome 2B6 was predominantly expressed in the right ventricle. A strong correlation between tissue-specific gene expression and enzyme activity was found.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 2B6 (CYP2B6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 2B6 (CYP2B6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 2B6 (CYP2B6) Polyclonal Antibody Customized Service Offer
Assay Kits SED300Hu ELISA Kit for Cytochrome P450 2B6 (CYP2B6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD300Mu01 Recombinant Cytochrome P450 2B6 (CYP2B6) Positive Control; Immunogen; SDS-PAGE; WB.
RPD300Mu02 Recombinant Cytochrome P450 2B6 (CYP2B6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD300Mu01 Polyclonal Antibody to Cytochrome P450 2B6 (CYP2B6) WB; IHC; ICC; IP.
PAD300Mu02 Polyclonal Antibody to Cytochrome P450 2B6 (CYP2B6) WB; IHC; ICC; IP.
Assay Kits SED300Mu ELISA Kit for Cytochrome P450 2B6 (CYP2B6) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver."Biochemistry 28:7340-7348(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages."Nucleic Acids Res. 17:8241-8255(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Gene expression in distinct regions of the heart."Lancet 355:979-983(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes."Xenobiotica 31:713-723(2001) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution."Mol. Pharmacol. 77:529-538(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains."Mol. Pharmacol. 80:1047-1055(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules."Biochemistry 51:7225-7238(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study."AIDS 18:2391-2400(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort."J. Antimicrob. Chemother. 65:1889-1893(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients."Pharmacogenomics 11:1223-1234(2010) [PubMed] [Europe PMC] [Abstract]
  14. "A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation."Biochem. Biophys. Res. Commun. 281:1256-1260(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver."Pharmacogenetics 11:399-415(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Functional characterization of cytochrome P450 2B6 allelic variants."Drug Metab. Dispos. 31:398-403(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population."J. Hum. Genet. 48:249-270(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression."J. Pharmacol. Exp. Ther. 307:906-922(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles."J. Pharmacol. Exp. Ther. 311:34-43(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]