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Cytochrome P450 2D6 (CYP2D6)

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CYP2D; P450C2D; CPD6; CYP2DL1; P450-DB1; Cytochrome P450 Family 2 Subfamily D Polypeptide 6; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase

Cytochrome P450 2D6 (CYP2D6)
CCC D302
HGNC 2625
MGI 1929474
PubMed 9241659
RGD 620640
UniProt P10635
Wiki CYP2D6
Cytochrome P450 2D6 (CYP2D6), a member of the cytochrome P450 mixed-function oxidase system, is one of the most important enzymes involved in the metabolism of xenobiotics in the body. Whilst CYP2D6 is involved in the oxidation of a wide range of substrates of all the CYPs, there is considerable variability in its expression in the liver. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. CYP2D6 activity was tested in "healthy infants receiving an oral dose (0.3 mg/kg) of dextromethorphan (DM) at 0.5, 1, 2, 4, 6, and 12 months of age. DM and its major metabolites were measured in urine. CYP2D6 genotype was determined by polymerase chain reaction-restriction fragment length polymorphism.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD302Hu01 Recombinant Cytochrome P450 2D6 (CYP2D6) Positive Control; Immunogen; SDS-PAGE; WB.
APD302Hu01 Active Cytochrome P450 2D6 (CYP2D6) Cell culture; Activity Assays.
Antibodies PAD302Hu01 Polyclonal Antibody to Cytochrome P450 2D6 (CYP2D6) WB; IHC; ICC; IP.
LAD302Hu71 Biotin-Linked Polyclonal Antibody to Cytochrome P450 2D6 (CYP2D6) WB; IHC; ICC.
Assay Kits SED302Hu ELISA Kit for Cytochrome P450 2D6 (CYP2D6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 2D6 (CYP2D6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 2D6 (CYP2D6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 2D6 (CYP2D6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 2D6 (CYP2D6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 2D6 (CYP2D6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD302Ra01 Recombinant Cytochrome P450 2D6 (CYP2D6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD302Ra01 Polyclonal Antibody to Cytochrome P450 2D6 (CYP2D6) WB; IHC; ICC; IP.
MAD302Ra21 Monoclonal Antibody to Cytochrome P450 2D6 (CYP2D6) WB; IHC; ICC; IP.
Assay Kits SED302Ra ELISA Kit for Cytochrome P450 2D6 (CYP2D6) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Characterization of the common genetic defect in humans deficient in debrisoquine metabolism."Nature 331:442-446(1988) [PubMed] [Europe PMC] [Abstract]
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  10. "Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype."Pharmacogenetics 1:26-32(1991) [PubMed] [Europe PMC] [Abstract]
  11. "Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism."Pharmacogenetics 3:256-263(1993) [PubMed] [Europe PMC] [Abstract]
  12. "A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine."Naunyn Schmiedebergs Arch. Pharmacol. 350:434-439(1994) [PubMed] [Europe PMC] [Abstract]
  13. "An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution."Hum. Genet. 95:337-341(1995) [PubMed] [Europe PMC] [Abstract]
  14. "A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity."Br. J. Clin. Pharmacol. 42:713-719(1996) [PubMed] [Europe PMC] [Abstract]
  15. "An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine."Hum. Genet. 97:668-670(1996) [PubMed] [Europe PMC] [Abstract]
  16. "Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution."Pharmacogenetics 7:193-202(1997) [PubMed] [Europe PMC] [Abstract]
  17. "G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese."Drug Metab. Dispos. 27:385-388(1999) [PubMed] [Europe PMC] [Abstract]
  18. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
  19. "In vitro functional assessment of 22 newly identified CYP2D6 allelic variants in the Chinese population."Basic Clin. Pharmacol. Toxicol. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]