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Cytochrome P450 2F1 (CYP2F1)

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CYP2F; C2F1; Cytochrome P450 Family 2 Subfamily F Polypeptide 1

Cytochrome P450 2F1 (CYP2F1)
CCC D303
HGNC 2632
MGI 88608
PubMed 10383923
RGD 2476
UniProt P24903
Wiki CYP2F1
Cytochrome P450 2F1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.Expressed in lung. Rarely detected in liver and placenta.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 2F1 (CYP2F1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 2F1 (CYP2F1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 2F1 (CYP2F1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 2F1 (CYP2F1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 2F1 (CYP2F1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 2F1 (CYP2F1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 2F1 (CYP2F1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 2F1 (CYP2F1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 2F1 (CYP2F1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 2F1 (CYP2F1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome P450 2F1 (CYP2F1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome P450 2F1 (CYP2F1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome P450 2F1 (CYP2F1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome P450 2F1 (CYP2F1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 2F1 (CYP2F1) ELISA Kit Customized Service Offer
  1. "The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping."Biochemistry 29:5491-5499(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and cross-species comparisons of CYP2F subfamily genes in mammals."Mutat. Res. 499:155-161(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant."Mutat. Res. 617:79-89(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta."Biochem. Pharmacol. 51:403-411(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding."J. Pharmacol. Exp. Ther. 276:21-29(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells."Drug Metab. Dispos. 27:798-803(1999) [PubMed] [Europe PMC] [Abstract]