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Cytochrome b-245 Alpha Polypeptide (CYBa)

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p22-PHOX; Flavocytochrome b-558 Alpha Polypeptide; Neutrophil cytochrome b 22 kDa; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome

Cytochrome b-245 Alpha Polypeptide (CYBa)
CCC D307
HGNC 2577
MGI 1316658
PubMed 18184111
RGD 620573
UniProt P13498
Wiki CYBA
Cytochrome b is composed of a light chain (alpha) and a heavy chain (beta). Cytochrome b-245 light chain is the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.The CYBA gene encodes the alpha subunit, also known as the light chain, of cytochrome b(-245), which is a component of the NADPH oxidase (NOX) complex responsible for the respiratory burst in phagocytes.The CYBB gene is an X-linked gene which encodes the cytochrome b beta subunit, also known as the heavy chain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome b-245 Alpha Polypeptide (CYBa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome b-245 Alpha Polypeptide (CYBa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome b-245 Alpha Polypeptide (CYBa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome b-245 Alpha Polypeptide (CYBa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome b-245 Alpha Polypeptide (CYBa) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome b-245 Alpha Polypeptide (CYBa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome b-245 Alpha Polypeptide (CYBa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome b-245 Alpha Polypeptide (CYBa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome b-245 Alpha Polypeptide (CYBa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome b-245 Alpha Polypeptide (CYBa) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome b-245 Alpha Polypeptide (CYBa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome b-245 Alpha Polypeptide (CYBa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome b-245 Alpha Polypeptide (CYBa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome b-245 Alpha Polypeptide (CYBa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome b-245 Alpha Polypeptide (CYBa) ELISA Kit Customized Service Offer
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  2. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
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  6. "Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases."J. Biol. Chem. 278:25234-25246(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Site-specific inhibitors of NADPH oxidase activity and structural probes of flavocytochrome b: characterization of six monoclonal antibodies to the p22phox subunit."J. Immunol. 173:7349-7357(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a novel partner of duox: EFP1, a thioredoxin-related protein."J. Biol. Chem. 280:3096-3103(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators."J. Biol. Chem. 280:23328-23339(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases."Cell. Signal. 18:69-82(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding."J. Biol. Chem. 285:2959-2967(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Molecular interface of S100A8 with cytochrome b and NADPH oxidase activation."PLoS ONE 7:E40277-E40277(2012) [PubMed] [Europe PMC] [Abstract]
  13. "NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide."J. Biol. Chem. 281:3660-3668(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Cytochrome b558-negative, autosomal recessive chronic granulomatous disease: two new mutations in the cytochrome b558 light chain of the NADPH oxidase (p22-phox)."Am. J. Hum. Genet. 51:1127-1135(1992) [PubMed] [Europe PMC] [Abstract]
  15. "Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease."Proc. Natl. Acad. Sci. U.S.A. 88:11231-11235(1991) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of allele-specific p22-phox mutations in a compound heterozygous patient with chronic granulomatous disease by mismatch PCR and restriction enzyme analysis."Hum. Genet. 93:437-442(1994) [PubMed] [Europe PMC] [Abstract]
  17. "156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox."J. Exp. Med. 180:2329-2334(1994) [PubMed] [Europe PMC] [Abstract]
  18. "Molecular analysis of 9 new families with chronic granulomatous disease caused by mutations in CYBA, the gene encoding p22(phox)."Blood 96:1106-1112(2000) [PubMed] [Europe PMC] [Abstract]
  19. "Genetic studies of three Japanese patients with p22-phox-deficient chronic granulomatous disease: detection of a possible common mutant CYBA allele in Japan and a genotype-phenotype correlation in these patients."Br. J. Haematol. 108:511-517(2000) [PubMed] [Europe PMC] [Abstract]
  20. "Statistical and mutational analysis of chronic granulomatous disease in Japan with special reference to gp91-phox and p22-phox deficiency."Hum. Genet. 106:473-481(2000) [PubMed] [Europe PMC] [Abstract]
  21. "Characterization of six novel mutations in CYBA: the gene causing autosomal recessive chronic granulomatous disease."Br. J. Haematol. 141:848-851(2008) [PubMed] [Europe PMC] [Abstract]
  22. "Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation."Hum. Mutat. 30:1123-1133(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Clinical, functional, and genetic characterization of chronic granulomatous disease in 89 Turkish patients."J. Allergy Clin. Immunol. 132:1156-1163(2013) [PubMed] [Europe PMC] [Abstract]