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Cytochrome b-245 Beta Polypeptide (CYBb)

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CGD; GP91PHOX; NOX2; Neutrophil cytochrome b91; Cytochrome b558 beta; Heme-binding membrane glycoprotein gp91phox; Superoxide-generating NADPH oxidase heavy chain

Cytochrome b-245 Beta Polypeptide (CYBb)
CCC D308
HGNC 2578
MGI 88574
PubMed 18278805
RGD 620574
UniProt P04839
Wiki CYBB
Cytochrome b-245, beta polypeptide is aglycoprotein.Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain.
It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD308Hu01 Recombinant Cytochrome b-245 Beta Polypeptide (CYBb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD308Hu01 Polyclonal Antibody to Cytochrome b-245 Beta Polypeptide (CYBb) WB; IHC; ICC; IP.
MAD308Hu21 Monoclonal Antibody to Cytochrome b-245 Beta Polypeptide (CYBb) WB; IHC; ICC; IP.
Assay Kits SED308Hu ELISA Kit for Cytochrome b-245 Beta Polypeptide (CYBb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome b-245 Beta Polypeptide (CYBb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome b-245 Beta Polypeptide (CYBb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome b-245 Beta Polypeptide (CYBb) Polyclonal Antibody Customized Service Offer
Assay Kits SED308Mu ELISA Kit for Cytochrome b-245 Beta Polypeptide (CYBb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome b-245 Beta Polypeptide (CYBb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome b-245 Beta Polypeptide (CYBb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome b-245 Beta Polypeptide (CYBb) Polyclonal Antibody Customized Service Offer
Assay Kits SED308Ra ELISA Kit for Cytochrome b-245 Beta Polypeptide (CYBb) Enzyme-linked immunosorbent assay for Antigen Detection.
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  19. ErratumBlood 89:1843-1843(1996)
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  28. "Characterization of 11 novel mutations in the X-linked chronic granulomatous disease (CYBB gene)."Hum. Mutat. 18:163-163(2001) [PubMed] [Europe PMC] [Abstract]
  29. "Molecular and functional characterization of a new X-linked chronic granulomatous disease variant (X91+) case with a double missense mutation in the cytosolic gp91phox C-terminal tail."Biochim. Biophys. Acta 1586:316-330(2002) [PubMed] [Europe PMC] [Abstract]
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