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Cytochrome b Reductase 1 (CYBRD1)

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DCYTB; FRRS3; Ferric-Chelate Reductase 3; Duodenal Cytochrome b

Cytochrome b Reductase 1 (CYBRD1)
CCC D309
HGNC 20797
MGI 2654575
PubMed 15961514
RGD 1305740
UniProt Q53TN4
DCYTB encodes a protein with 6 predicted transmembrane domains and 4 conserved histidine residues which are proposed heme ligands. DCYTB shares 45 to 50% similarity with the cytochrome b561 family of plasma membrane reductases, is highly expressed in the brush-border membrane of duodenal enterocytes, and induces ferric reductase activity when expressed in Xenopus oocytes and cultured cells.
Duodenal expression levels of DCYTB mRNA and protein were regulated by changes in physiologic modulators of iron absorption, including chronic anemia, iron deficiency, and hypoxia. Three major transcripts of 1, 4, and greater than 5 kb were detectable by Northern blot analysis, indicative of alternative splicing or the presence of unprocessed pre-mRNA species.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome b Reductase 1 (CYBRD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome b Reductase 1 (CYBRD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome b Reductase 1 (CYBRD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome b Reductase 1 (CYBRD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome b Reductase 1 (CYBRD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome b Reductase 1 (CYBRD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome b Reductase 1 (CYBRD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome b Reductase 1 (CYBRD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome b Reductase 1 (CYBRD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome b Reductase 1 (CYBRD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytochrome b Reductase 1 (CYBRD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytochrome b Reductase 1 (CYBRD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytochrome b Reductase 1 (CYBRD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytochrome b Reductase 1 (CYBRD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome b Reductase 1 (CYBRD1) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload."Hum. Genet. 115:409-417(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis."Gastroenterology 125:746-754(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis." Br. J. Haematol. 147:140-149(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Gene symbol: DCYTB/CYBRD1. Disease: primary iron overload."Hum. Genet. 118:546-546(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Gene symbol: DCYTB/CYBRD1. Disease: primary iron overload."Hum. Genet. 118:548-549(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Gene symbol: DCYTB/CYBRD1. Disease: primary iron overload."Hum. Genet. 118:549-549(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Immunolocalization of duodenal cytochrome B: a relationship with circulating markers of iron status."Eur. J. Clin. Invest. 36:890-898(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Human erythrocyte membranes contain a cytochrome b561 that may be involved in extracellular ascorbate recycling."J. Biol. Chem. 281:39852-39859(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells."Am. J. Physiol. 291:L272-L280(2006) [PubMed] [Europe PMC] [Abstract]