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Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b)

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CAM2; CAMK2; CAMKB; Proline Rich Calmodulin-Dependent Protein Kinase

Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b)
CCC D332
HGNC 1461
MGI 88257
PubMed 21871176
RGD 2262
UniProt Q13554
Wiki CAMK2B
Calcium/calmodulin-dependent protein kinase type II beta chain is an enzyme belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta.
The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD332Hu01 Recombinant Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD332Hu01 Polyclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b) WB; IHC; ICC; IP.
MAD332Hu21 Monoclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b) WB; IHC; ICC; IP.
Assay Kits SED332Hu ELISA Kit for Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium/Calmodulin Dependent Protein Kinase II Beta (CAMK2b) ELISA Kit Customized Service Offer
  1. "Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities."FEBS Lett. 475:107-110(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells."Diabetologia 43:465-473(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of novel human tumor cell-specific CaMK-II variants."Biochim. Biophys. Acta 1355:281-292(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II."J. Biol. Chem. 279:12484-12494(2004) [PubMed] [Europe PMC] [Abstract]
  8. "SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation."Neuron 43:563-574(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise."J. Physiol. (Lond.) 574:889-903(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Analysis of CaM-kinase signaling in cells."Cell Calcium 50:1-8(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis."Proc. Nutrit. Soc. 63:279-286(2004) [PubMed] [Europe PMC] [Abstract]
  13. "The Ca2+-calmodulin dependent protein kinase II system of skeletal muscle sarcoplasmic reticulum."Basic Appl. Myol. 15:5-17(2005)
  14. "Calmodulin-kinases: modulators of neuronal development and plasticity."Neuron 59:914-931(2008) [PubMed] [Europe PMC] [Abstract]
  15. "The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag?"Physiology (Bethesda) 24:357-366(2009) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of human calcium/calmodulin-dependent protein kinase IIb isoform 1 (CAMK2B)."Submitted (DEC-2007) to the PDB data bank
  18. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]