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Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d)

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CAMKD; Calcium/Calmodulin-Dependent Protein Kinase Type II Delta Chain

Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d)
CCC D333
HGNC 1462
MGI 1341265
PubMed 11451385
RGD 2263
UniProt Q13557
Wiki CAMK2D
CAMK2D belongs to a family of type II multifunctional calcium- and calmodulin-dependent protein kinases. There are at least 4 CAMK2 genes, and each can yield several isoforms through alternative splicing. CAMK2 isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses.
In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Four alternatively spliced transcript variants that encode three different isoforms have been characterized to date. Distinct isoforms of this chain have different expression patterns.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium/Calmodulin Dependent Protein Kinase II Delta (CAMK2d) ELISA Kit Customized Service Offer
  1. "Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium."Circ. Res. 84:713-721(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells."Diabetologia 43:465-473(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of novel human tumor cell-specific CaMK-II variants."Biochim. Biophys. Acta 1355:281-292(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II."J. Biol. Chem. 279:12484-12494(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise."J. Physiol. (Lond.) 574:889-903(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells."J. Biol. Chem. 282:7219-7231(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart."Cardiovasc. Res. 73:631-640(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Cardiac ryanodine receptor phosphorylation by CaM Kinase II: keeping the balance right."Front. Biosci. 14:5134-5156(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Role of CaMKII in cardiovascular health, disease, and arrhythmia."Heart Rhythm 8:142-144(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation."PLoS Biol. 8:E1000426-E1000426(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Calmodulin bound to peptide from calmodulin kinase II (CaMKII)."Submitted (MAR-2009) to the PDB data bank
  23. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]