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Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g)

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ENaCg; ENaCgamma; PHA1; SCNEG; Sodium Channel,Nonvoltage-Gated 1,Alpha; Epithelial Na(+) channel subunit gamma; Nonvoltage-gated sodium channel 1 subunit gamma

Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g)
CCC D335
HGNC 10602
MGI 104695
PubMed 8575777
RGD 3641
UniProt P51170
Wiki SCNN1G
The epithelial sodium channel (short: ENaC, also: sodium channel non-neuronal 1 (SCNN1) or amiloride sensitive sodium channel (ASSC)) is a membrane-bound ion-channel that is permeable for Li+-ions, protons and especially Na+-ions. It is a constitutively active ion-channel. It is arguably the most selective ion channel.
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. Amiloride Sensitive Sodium Channel Subunit Gammaisthe gamma subunit, and mutations in this gene have been associated with Liddle syndrome..

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD335Hu01 Recombinant Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) Positive Control; Immunogen; SDS-PAGE; WB.
RPD335Hu02 Recombinant Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD335Hu01 Polyclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) WB; IHC; ICC; IP.
MAD335Hu21 Monoclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) WB,IHC
MAD335Hu22 Monoclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) WB; IHC; ICC; IP.
Assay Kits SED335Hu ELISA Kit for Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amiloride Sensitive Sodium Channel Subunit Gamma (SCNN1g) ELISA Kit Customized Service Offer
  1. "Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel."Genomics 28:560-565(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel."Am. J. Physiol. 268:C1157-C1163(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel alpha-, beta-, and gamma-subunit genes."J. Clin. Endocrinol. Metab. 87:3344-3350(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic organization and the 5' flanking region of the gamma subunit of the human amiloride-sensitive epithelial sodium channel."J. Biol. Chem. 271:26062-26066(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome."Nat. Genet. 11:76-82(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of novel human WW domain-containing proteins by cloning of ligand targets."J. Biol. Chem. 272:14611-14616(1997) [PubMed] [Europe PMC] [Abstract]
  8. "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel."J. Biol. Chem. 276:8597-8601(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel."Am. J. Physiol. 283:F431-F436(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation."J. Biol. Chem. 283:25290-25295(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Genetic analysis of Rwandan patients with cystic fibrosis-like symptoms: identification of novel cystic fibrosis transmembrane conductance regulator and epithelial sodium channel gene variants."Chest 135:1233-1242(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways."Histochem. Cell Biol. 137:339-353(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)."J. Biol. Chem. 287:19266-19274(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures."Am. J. Physiol. 305:L990-L1001(2013) [PubMed] [Europe PMC] [Abstract]
  15. "ENaC modulators and renal disease."Curr. Mol. Pharmacol. 6:35-43(2013) [PubMed] [Europe PMC] [Abstract]
  16. "Polymorphisms of amiloride-sensitive sodium channel subunits in five sporadic cases of pseudohypoaldosteronism: do they have pathologic potential?"J. Clin. Endocrinol. Metab. 84:2434-2437(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
  18. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Could a defective epithelial sodium channel lead to bronchiectasis."Respir. Res. 9:46-46(2008) [PubMed] [Europe PMC] [Abstract]