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Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b)

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ENaCb; ENaCbeta; SCNEB; Liddle Syndrome; Sodium Channel,Nonvoltage-Gated 1,Beta; Epithelial Na(+) channel subunit beta; Nonvoltage-gated sodium channel 1 subunit beta

Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b)
CCC D336
HGNC 10600
MGI 104696
PubMed 16943574
RGD 3640
UniProt P51168
Wiki SCNN1B
The epithelial sodium channel (short: ENaC, also: sodium channel non-neuronal 1 (SCNN1) or amiloride sensitive sodium channel (ASSC)) is a membrane-bound ion-channel that is permeable for Li+-ions, protons and especially Na+-ions. It is a constitutively active ion-channel. It is arguably the most selective ion channel.
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This SCNN1b encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD336Hu01 Recombinant Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD336Hu01 Polyclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b) WB; IHC; ICC; IP.
MAD336Hu21 Monoclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b) WB; IHC; ICC; IP.
Assay Kits SED336Hu ELISA Kit for Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amiloride Sensitive Sodium Channel Subunit Beta (SCNN1b) ELISA Kit Customized Service Offer
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  28. "Polymorphisms of amiloride-sensitive sodium channel subunits in five sporadic cases of pseudohypoaldosteronism: do they have pathologic potential?"J. Clin. Endocrinol. Metab. 84:2434-2437(1999) [PubMed] [Europe PMC] [Abstract]
  29. "A new mutation, R563Q, of the beta subunit of the epithelial sodium channel associated with low-renin, low-aldosterone hypertension."J. Hypertens. 21:921-926(2003) [PubMed] [Europe PMC] [Abstract]
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