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Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a)

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ENaCa; ENaCalpha; SCNEA; SCNN1; Sodium Channel,Nonvoltage-Gated 1,Alpha; Epithelial Na(+) channel subunit alpha; Nonvoltage-gated sodium channel 1 subunit alpha

Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a)
CCC D337
HGNC 10599
MGI 101782
PubMed 22776878
RGD 3639
UniProt P37088
Wiki SCNN1A
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. Amiloride Sensitive Sodium Channel Subunit Alpha is the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD337Hu01 Recombinant Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD337Hu01 Polyclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) WB; IHC; ICC; IP.
MAD337Hu21 Monoclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) WB; IHC; ICC; IP.
Assay Kits SED337Hu ELISA Kit for Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD337Mu01 Recombinant Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD337Mu01 Polyclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD337Ra01 Recombinant Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD337Ra01 Polyclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) WB; IHC; ICC; IP.
MAD337Ra21 Monoclonal Antibody to Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) WB; IHC; ICC; IP.
Assay Kits SED337Ra ELISA Kit for Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1a) Enzyme-linked immunosorbent assay for Antigen Detection.
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  23. ErratumHypertension 41:1E-1E(2003)
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  25. "Polymorphisms of amiloride-sensitive sodium channel subunits in five sporadic cases of pseudohypoaldosteronism: do they have pathologic potential?"J. Clin. Endocrinol. Metab. 84:2434-2437(1999) [PubMed] [Europe PMC] [Abstract]
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