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Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3)

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ASIC3; SLNAC1; TNaC1; Testis Sodium Channel 1; Acid-sensing ion channel 3; Neuronal amiloride-sensitive cation channel 3

Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3)
CCC D338
HGNC 101
MGI 2159339
PubMed 21070287
RGD 708578
UniProt Q9UHC3
Wiki ACCN3
Amiloride-sensitive cation channel 3 is a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium. Alternative splicing of this gene generates three transcript variants encoding distinct isoforms.Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Amiloride Sensitive Cation Channel Protein 3, Testis (ACCN3) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis."Biochem. Biophys. Res. Commun. 245:589-593(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel."FEBS Lett. 433:257-260(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties."J. Neurochem. 72:51-57(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+."J. Biol. Chem. 275:28519-28525(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Selective modulation of heteromeric ASIC proton-gated channels by neuropeptide FF."Neuropharmacology 41:592-600(2001) [PubMed] [Europe PMC] [Abstract]
  7. "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1."Proc. Natl. Acad. Sci. U.S.A. 100:2029-2034(2003) [PubMed] [Europe PMC] [Abstract]
  8. "PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current."J. Biol. Chem. 279:46962-46968(2004) [PubMed] [Europe PMC] [Abstract]