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Casein Kinase 2 Alpha 1 (CSNK2a1)

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CK2A1; CKII; CKII alpha

Casein Kinase 2 Alpha 1 (CSNK2a1)
CCC D342
HGNC 2457
MGI 88543
PubMed 20671611
RGD 621663
UniProt P68400
Wiki CSNK2A1
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation.
Casein kinase II subunit alpha is an enzyme represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Casein Kinase 2 Alpha 1 (CSNK2a1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Casein Kinase 2 Alpha 1 (CSNK2a1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Casein Kinase 2 Alpha 1 (CSNK2a1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Casein Kinase 2 Alpha 1 (CSNK2a1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casein Kinase 2 Alpha 1 (CSNK2a1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Casein Kinase 2 Alpha 1 (CSNK2a1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Casein Kinase 2 Alpha 1 (CSNK2a1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Casein Kinase 2 Alpha 1 (CSNK2a1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Casein Kinase 2 Alpha 1 (CSNK2a1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casein Kinase 2 Alpha 1 (CSNK2a1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Casein Kinase 2 Alpha 1 (CSNK2a1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Casein Kinase 2 Alpha 1 (CSNK2a1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Casein Kinase 2 Alpha 1 (CSNK2a1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Casein Kinase 2 Alpha 1 (CSNK2a1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casein Kinase 2 Alpha 1 (CSNK2a1) ELISA Kit Customized Service Offer
  1. "Molecular cloning of the human casein kinase II alpha subunit."Biochemistry 28:4072-4076(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II."Biochemistry 29:8436-8447(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Structure and sequence of an intronless gene for human casein kinase II-alpha subunit."FEBS Lett. 316:114-118(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphorylation of casein kinase II by p34cdc2. Identification of phosphorylation sites using phosphorylation site mutants in vitro."J. Biol. Chem. 270:25872-25878(1995) [PubMed] [Europe PMC] [Abstract]
  9. "A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1."Mol. Cell 7:283-292(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells."Oncogene 20:6994-7005(2001) [PubMed] [Europe PMC] [Abstract]
  11. "p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex."J. Biol. Chem. 277:50206-50213(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8."EMBO J. 24:3532-3542(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation."Mol. Cell. Biol. 25:1446-1457(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Evidence for regulation of mitotic progression through temporal phosphorylation and dephosphorylation of CK2alpha."Mol. Cell. Biol. 29:2068-2081(2009) [PubMed] [Europe PMC] [Abstract]
  16. "One-thousand-and-one substrates of protein kinase CK2?"FASEB J. 17:349-368(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights."Cell. Mol. Life Sci. 66:1800-1816(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival."Cell. Mol. Life Sci. 66:1817-1829(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair."Cell. Mol. Life Sci. 66:1830-1839(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery."Cell. Mol. Life Sci. 66:1840-1849(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer."Cell. Mol. Life Sci. 66:1850-1857(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A."Mol. Biol. Cell 21:244-253(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer."PLoS ONE 5:E11418-E11418(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  26. "The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA."Cancer Res. 72:2275-2284(2012) [PubMed] [Europe PMC] [Abstract]
  27. "Crystallization and preliminary characterization of crystals of human protein kinase CK2."Acta Crystallogr. D 56:1680-1684(2000) [PubMed] [Europe PMC] [Abstract]
  28. "Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme."EMBO J. 20:5320-5331(2001) [PubMed] [Europe PMC] [Abstract]
  29. "Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2."Acta Crystallogr. D 59:2133-2139(2003) [PubMed] [Europe PMC] [Abstract]
  30. "Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit."J. Mol. Biol. 330:925-934(2003) [PubMed] [Europe PMC] [Abstract]