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Casein Kinase 2 Beta (CSNK2b)

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CK2B; CK2N; CSK2B; G5A; Phosvitin; Casein kinase II subunit beta

Casein Kinase 2 Beta (CSNK2b)
CCC D343
HGNC 2460
MGI 88548
PubMed 23521802
UniProt P67870
Wiki CSNK2B
Casein kinase II subunit beta is the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication.
The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus.The deduced nucleotide sequence was used for the synthesis of a mixture of 20-mers as a hybridization probe to screen a lambda-gt10 HeLa cell cDNA library for clones encoding the beta subunit. The beta subunit presumably serves regulatory functions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Casein Kinase 2 Beta (CSNK2b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Casein Kinase 2 Beta (CSNK2b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Casein Kinase 2 Beta (CSNK2b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Casein Kinase 2 Beta (CSNK2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casein Kinase 2 Beta (CSNK2b) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Casein Kinase 2 Beta (CSNK2b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Casein Kinase 2 Beta (CSNK2b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Casein Kinase 2 Beta (CSNK2b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Casein Kinase 2 Beta (CSNK2b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casein Kinase 2 Beta (CSNK2b) ELISA Kit Customized Service Offer
  1. "Human phosvitin/casein kinase type II. Molecular cloning and sequencing of full-length cDNA encoding subunit beta."Eur. J. Biochem. 183:227-233(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells."Mutat. Res. 236:85-97(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II."Biochemistry 28:9053-9058(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Structure of the gene encoding human casein kinase II subunit beta."J. Biol. Chem. 266:13706-13711(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line."Biochemistry 41:8935-8940(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit."Proc. Natl. Acad. Sci. U.S.A. 87:821-825(1990) [PubMed] [Europe PMC] [Abstract]
  11. "Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C."Eur. J. Immunol. 31:999-1009(2001) [PubMed] [Europe PMC] [Abstract]
  12. "A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1."Mol. Cell 7:283-292(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor."J. Biol. Chem. 277:23864-23871(2002) [PubMed] [Europe PMC] [Abstract]
  14. "p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex."J. Biol. Chem. 277:50206-50213(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction."Genes Dev. 20:1800-1816(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization."EMBO J. 18:2930-2940(1999) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme."EMBO J. 20:5320-5331(2001) [PubMed] [Europe PMC] [Abstract]