≡

Casein Kinase 2 Alpha 2 (CSNK2a2)

[Edit]

CSNK2A1; CK2A2; Casein kinase II subunit alpha'

Casein Kinase 2 Alpha 2 (CSNK2a2)
CCC D344
HGNC 2459
MGI 88547
PubMed 10782213
RGD 1306882
UniProt P19784
Wiki CSNK2A2
Casein kinase II catalyzes the phosphorylation of serine or threonine residues in proteins; i.e., it is a protein serine / threonine kinase. The enzyme is probably present in all eukaryotic cells, implying that it has fundamental cellular functions. The holoenzyme is a tetramer containing 2 alpha or alpha-prime subunits (or one of each) and 2 beta subunits. The function of the beta subunit is unknown but presumably it fills a regulatory role in the holoenzyme. The alpha subunit is the catalytic subunit. Angiotensin II, a potent inducer of cardiomyocyte hypertrophy, induced proteasomal degradation of p27 in primary rat cardiomyocytes through CK2-alpha-prime-dependent phosphorylation of p27 on ser83 and thr187, which are conserved in human and rodents. Conversely, unphosphorylated p27 potently inhibited CK2-alpha-prime.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Casein Kinase 2 Alpha 2 (CSNK2a2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Casein Kinase 2 Alpha 2 (CSNK2a2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Casein Kinase 2 Alpha 2 (CSNK2a2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Casein Kinase 2 Alpha 2 (CSNK2a2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casein Kinase 2 Alpha 2 (CSNK2a2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Casein Kinase 2 Alpha 2 (CSNK2a2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Casein Kinase 2 Alpha 2 (CSNK2a2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Casein Kinase 2 Alpha 2 (CSNK2a2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Casein Kinase 2 Alpha 2 (CSNK2a2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casein Kinase 2 Alpha 2 (CSNK2a2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Casein Kinase 2 Alpha 2 (CSNK2a2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Casein Kinase 2 Alpha 2 (CSNK2a2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Casein Kinase 2 Alpha 2 (CSNK2a2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Casein Kinase 2 Alpha 2 (CSNK2a2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casein Kinase 2 Alpha 2 (CSNK2a2) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II."Biochemistry 29:8436-8447(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1."Mol. Cell 7:283-292(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells."Oncogene 20:6994-7005(2001) [PubMed] [Europe PMC] [Abstract]
  5. "p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex."J. Biol. Chem. 277:50206-50213(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8."EMBO J. 24:3532-3542(2005) [PubMed] [Europe PMC] [Abstract]
  7. "One-thousand-and-one substrates of protein kinase CK2?"FASEB J. 17:349-368(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights."Cell. Mol. Life Sci. 66:1800-1816(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival."Cell. Mol. Life Sci. 66:1817-1829(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair."Cell. Mol. Life Sci. 66:1830-1839(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery."Cell. Mol. Life Sci. 66:1840-1849(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer."Cell. Mol. Life Sci. 66:1850-1857(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Structure of human protein kinase CK2 alpha 2 with a potent indazole-derivative inhibitor."Acta Crystallogr. F 65:75-79(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Structure of the human protein kinase CK2 catalytic subunit CK2alpha' and interaction thermodynamics with the regulatory subunit CK2beta."J. Mol. Biol. 407:1-12(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]