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Interleukin 17 Receptor D (IL17RD)

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SEF; IL17RLM; IL-17RD; IL17R-D; IL17Rhom; Interleukin-17 receptor-like protein

Interleukin 17 Receptor D (IL17RD)
CCC D349
HGNC 17616
MGI 2159727
PubMed 23047677
RGD 1565237
UniProt Q8NFM7
Fibroblast growth factors (FGFs) are secreted proteins involved in cellular proliferation, migration, differentiation, and survival. FGF activity is negatively regulated by members of the 'sprouty' family . The SEF protein is a modulator of FGF signaling. The genomic coordinates used for the transcript record were based on transcript alignments.
Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting tubules of the kidney. Isoform 1 is also highly expressed in both fetal and adult brain, pituarity, tonsils, spleen, adenoids, fetal kidney, liver, testes and ovary.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD349Hu01 Recombinant Interleukin 17 Receptor D (IL17RD) Positive Control; Immunogen; SDS-PAGE; WB.
APD349Hu01 Active Interleukin 17 Receptor D (IL17RD) Cell culture; Activity Assays.
Antibodies PAD349Hu01 Polyclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interleukin 17 Receptor D (IL17RD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 17 Receptor D (IL17RD) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD349Mu01 Recombinant Interleukin 17 Receptor D (IL17RD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD349Mu01 Polyclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interleukin 17 Receptor D (IL17RD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 17 Receptor D (IL17RD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD349Ra01 Recombinant Interleukin 17 Receptor D (IL17RD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD349Ra01 Polyclonal Antibody to Interleukin 17 Receptor D (IL17RD) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interleukin 17 Receptor D (IL17RD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 17 Receptor D (IL17RD) ELISA Kit Customized Service Offer
  1. "hSef inhibits PC-12 cell differentiation by interfering with Ras-mitogen-activated protein kinase MAPK signaling."J. Biol. Chem. 278:50273-50282(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity."Proc. Natl. Acad. Sci. U.S.A. 101:1229-1234(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A novel interleukin-17 receptor-like protein identified in human umbilical vein endothelial cells antagonizes basic fibroblast growth factor-induced signaling."J. Biol. Chem. 278:33232-33238(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Sef is a spatial regulator for Ras/MAP kinase signaling."Dev. Cell 7:33-44(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism." Am. J. Hum. Genet. 92:725-743(2013) [PubMed] [Europe PMC] [Abstract]