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Kruppel Like Factor 8 (KLF8)

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BKLF3; ZNF741; Basic krueppel-like factor 3; Zinc finger protein 741

Kruppel Like Factor 8 (KLF8)
CCC D363
HGNC 6351
MGI 2442430
PubMed 12820964
UniProt O95600
Wiki KLF8
Kruppel Like Factor 8 is a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers.
The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants.Transcriptional repressor and activator. Binds to CACCC- boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kruppel Like Factor 8 (KLF8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kruppel Like Factor 8 (KLF8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kruppel Like Factor 8 (KLF8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kruppel Like Factor 8 (KLF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kruppel Like Factor 8 (KLF8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kruppel Like Factor 8 (KLF8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kruppel Like Factor 8 (KLF8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kruppel Like Factor 8 (KLF8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kruppel Like Factor 8 (KLF8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kruppel Like Factor 8 (KLF8) ELISA Kit Customized Service Offer
  1. "Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors."FASEB J. 27:432-436(2013) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human Kruppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription."Nucleic Acids Res. 28:1955-1962(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression."Mol. Cell 11:1503-1515(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation."J. Biol. Chem. 281:16664-16671(2006) [PubMed] [Europe PMC] [Abstract]