≡

Thioredoxin Reductase 2 (TrxR2)

[Edit]

TR; TXNRD2; TR3; SelZ; Thioredoxin Reductase Beta; Selenoprotein Z

Thioredoxin Reductase 2 (TrxR2)
CCC D376
HGNC 18155
MGI 1347023
PubMed 15082714
RGD 61960
UniProt Q9NNW7
Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins.
TrxR2 partially overlaps the COMT gene on chromosome 22.Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Reductase 2 (TrxR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Reductase 2 (TrxR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Reductase 2 (TrxR2) Polyclonal Antibody Customized Service Offer
Assay Kits SED376Hu ELISA Kit for Thioredoxin Reductase 2 (TrxR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Reductase 2 (TrxR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Reductase 2 (TrxR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Reductase 2 (TrxR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Reductase 2 (TrxR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Reductase 2 (TrxR2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Reductase 2 (TrxR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Reductase 2 (TrxR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Reductase 2 (TrxR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Reductase 2 (TrxR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Reductase 2 (TrxR2) ELISA Kit Customized Service Offer
  1. "Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases."J. Biol. Chem. 274:24522-24530(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning, sequencing and functional expression of a novel human thioredoxin reductase."FEBS Lett. 442:105-111(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Human mitochondrial thioredoxin reductase: cDNA cloning, expression and genomic organization."Eur. J. Biochem. 261:405-412(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif."J. Biol. Chem. 274:38147-38154(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Heterogeneity within animal thioredoxin reductases: evidence for alternative first exon splicing."J. Biol. Chem. 276:3106-3114(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]