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Kallistatin (KAL)

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SERPINA4; KLST; KST; PI4; Serpin Peptidase Inhibitor Clade A Member 4; Tissue Kallikrein Inhibitor; Kallikrein Binding Protein; Peptidase inhibitor 4

Kallistatin (KAL)
CCC D392
HGNC 8948
MGI 2448363
PubMed 11258665
UniProt P29622
Wiki SERPINA4
Kallistatin is a serine proteinase inhibitor (serpin) and a heparin-binding protein. It is localized in vascular smooth muscle cells and endothelial cells of blood vessels, suggesting that it may be involved in the regulation of vascular function.The 1,284-bp cDNA encodes 427 amino acid residues, including a 26-residue signal peptide and a 401-residue mature peptide. The translated amino acid sequence of kallistatin matches the protein sequence and shares 44 to 46% sequence identity with human alpha-1-antichymotrypsin (AACT), alpha-1-antitrypsin (PI), corticosteroid-binding globulin (CBG), thyroxine-binding globulin of serum (TBG), and protein C inhibitor (PCI). All of these except TBG, which is encoded by the X chromosome, are encoded by genes on chromosome 14.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD392Hu01 Recombinant Kallistatin (KAL) Positive Control; Immunogen; SDS-PAGE; WB.
APD392Hu01 Active Kallistatin (KAL) Cell culture; Activity Assays.
Antibodies PAD392Hu01 Polyclonal Antibody to Kallistatin (KAL) WB; IHC; ICC; IP.
MAD392Hu21 Monoclonal Antibody to Kallistatin (KAL) WB; IHC; ICC; IP.
Assay Kits SED392Hu ELISA Kit for Kallistatin (KAL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kallistatin (KAL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kallistatin (KAL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kallistatin (KAL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kallistatin (KAL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kallistatin (KAL) ELISA Kit Customized Service Offer
  1. "Kallistatin: a novel human serine proteinase inhibitor. Molecular cloning, tissue distribution, and expression in Escherichia coli."J. Biol. Chem. 268:24498-24505(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning, sequence analysis, and chromosomal localization of the human protease inhibitor 4 (kallistatin) gene (PI4)."Genomics 23:370-378(1994) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Kallistatin: a novel human tissue kallikrein inhibitor. Purification, characterization, and reactive center sequence."J. Biol. Chem. 267:25873-25880(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  7. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]