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Protein C Inhibitor (PCI)

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SERPINA5; PAI3; PLANH3; PROCI; Serpin Peptidase Inhibitor Clade A 5; Plasma Serine Protease Inhibitor; Plasminogen Activator Inhibitor 3; Acrosomal serine protease inhibitor

Protein C Inhibitor (PCI)
CCC D393
HGNC 8723
MGI 107817
PubMed 24388360
RGD 619817
UniProt P05154
Wiki SERPINA5
Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor (serpin) which limits the expression of protein C.Suzuki et al. (1987) determined the sequence of cDNA for human protein C inhibitor (PCI). A high degree of homology of the deduced amino acid sequence to that of other known inhibitors clearly demonstrated that protein C inhibitor is a member of the superfamily of serine protease inhibitors including alpha-1-antichymotrypsin (AACT), alpha-1-antitrypsin (AAT; PI), antithrombin III (AT3), and angiotensinogen (AGT). Protein C inhibitor is sometimes referred to as plasminogen activator inhibitor-3 (PAI3) because it also inhibits plasminogen activators (Meijers and Chung, 1991). Plasminogen activator inhibitor-1 (PAI1) has structural similarities to PCI.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD393Hu01 Recombinant Protein C Inhibitor (PCI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD393Hu01 Polyclonal Antibody to Protein C Inhibitor (PCI) WB; ICC; IHC-P; IHC-F; ELISA.
MAD393Hu21 Monoclonal Antibody to Protein C Inhibitor (PCI) WB; IHC; ICC; IP.
Assay Kits SED393Hu ELISA Kit for Protein C Inhibitor (PCI) Enzyme-linked immunosorbent assay for Antigen Detection.
SCD393Hu CLIA Kit for Protein C Inhibitor (PCI) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein C Inhibitor (PCI) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein C Inhibitor (PCI) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein C Inhibitor (PCI) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein C Inhibitor (PCI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein C Inhibitor (PCI) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein C Inhibitor (PCI) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein C Inhibitor (PCI) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein C Inhibitor (PCI) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein C Inhibitor (PCI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein C Inhibitor (PCI) ELISA Kit Customized Service Offer
  1. "Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily."J. Biol. Chem. 262:611-616(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Evidence for a glycine residue at position 316 in human protein C inhibitor."Thromb. Res. 59:389-393(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Organization of the gene coding for human protein C inhibitor (plasminogen activator inhibitor-3). Assignment of the gene to chromosome 14."J. Biol. Chem. 266:15028-15034(1991) [PubMed] [Europe PMC] [Abstract]
  4. "Gene organization of human protein C inhibitor, a member of SERPIN family proteins encoded in five exons."Int. J. Hematol. 58:213-224(1993) [PubMed] [Europe PMC] [Abstract]
  5. "A two-allele polymorphism in protein C inhibitor with varying frequencies in different ethnic populations."Thromb. Haemost. 75:62-69(1996) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Human sperm-egg binding is inhibited by peptides corresponding to core region of an acrosomal serine protease inhibitor."Mol. Reprod. Dev. 34:280-291(1993) [PubMed] [Europe PMC] [Abstract]
  9. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Protein C inhibitor from human plasma: characterization of native and cleaved inhibitor and demonstration of inhibitor complexes with plasma kallikrein."Thromb. Haemost. 62:885-891(1989) [PubMed] [Europe PMC] [Abstract]
  11. "Mechanism of inhibition of activated protein C by protein C inhibitor."J. Biochem. 95:187-195(1984) [PubMed] [Europe PMC] [Abstract]
  12. "Inhibition of urokinase by protein C-inhibitor (PCI). Evidence for identity of PCI and plasminogen activator inhibitor 3."Biol. Chem. Hoppe-Seyler 368:1427-1433(1987) [PubMed] [Europe PMC] [Abstract]
  13. "Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor."Biochemistry 27:4231-4237(1988) [PubMed] [Europe PMC] [Abstract]
  14. "Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen."Thromb. Res. 64:309-320(1991) [PubMed] [Europe PMC] [Abstract]
  15. "Protein C inhibitor in human body fluids. Seminal plasma is rich in inhibitor antigen deriving from cells throughout the male reproductive system."J. Clin. Invest. 89:1094-1101(1992) [PubMed] [Europe PMC] [Abstract]
  16. "Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa."Am. J. Physiol. 267:C466-C472(1994) [PubMed] [Europe PMC] [Abstract]
  17. "Intermolecular interactions between protein C inhibitor and coagulation proteases."Biochemistry 34:12991-12997(1995) [PubMed] [Europe PMC] [Abstract]
  18. "Complexes of tissue kallikrein with protein C inhibitor in human semen and urine."Eur. J. Biochem. 234:641-649(1995) [PubMed] [Europe PMC] [Abstract]
  19. "Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor."Eur. J. Biochem. 238:88-96(1996) [PubMed] [Europe PMC] [Abstract]
  20. "Protein C inhibitor acts as a procoagulant by inhibiting the thrombomodulin-induced activation of protein C in human plasma."Blood 91:1542-1547(1998) [PubMed] [Europe PMC] [Abstract]
  21. "Protein C inhibitor may modulate human sperm-oocyte interactions."Biol. Reprod. 58:670-677(1998) [PubMed] [Europe PMC] [Abstract]
  22. "Protein C inhibitor secreted from activated platelets efficiently inhibits activated protein C on phosphatidylethanolamine of platelet membrane and microvesicles."J. Biol. Chem. 273:11281-11287(1998) [PubMed] [Europe PMC] [Abstract]
  23. "Functionally inactive protein C inhibitor in seminal plasma may be associated with infertility."Mol. Hum. Reprod. 5:513-519(1999) [PubMed] [Europe PMC] [Abstract]
  24. "Binding of retinoic acid by the inhibitory serpin protein C inhibitor."Eur. J. Biochem. 268:5989-5996(2001) [PubMed] [Europe PMC] [Abstract]
  25. "Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma."Int. J. Cancer 108:516-523(2004) [PubMed] [Europe PMC] [Abstract]
  26. "Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes."J. Biol. Chem. 279:46981-46994(2004) [PubMed] [Europe PMC] [Abstract]
  27. "Characterization of a novel human protein C inhibitor (PCI) gene transgenic mouse useful for studying the role of PCI in physiological and pathological conditions."J. Thromb. Haemost. 2:949-961(2004) [PubMed] [Europe PMC] [Abstract]
  28. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
  29. "Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity."Biochem. J. 390:231-242(2005) [PubMed] [Europe PMC] [Abstract]
  30. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  31. "Immunolocalization of protein C inhibitor in differentiation of human epidermal keratinocytes."Acta Histochem. 109:461-467(2007) [PubMed] [Europe PMC] [Abstract]
  32. "N-glycans and the N terminus of protein C inhibitor affect the cofactor-enhanced rates of thrombin inhibition."J. Biol. Chem. 283:18601-18611(2008) [PubMed] [Europe PMC] [Abstract]
  33. "Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex."Proc. Natl. Acad. Sci. U.S.A. 105:4661-4666(2008) [PubMed] [Europe PMC] [Abstract]
  34. "Further insight into the roles of the glycans attached to human blood protein C inhibitor."Biochem. Biophys. Res. Commun. 403:198-202(2010) [PubMed] [Europe PMC] [Abstract]
  35. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  36. "Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor."Proc. Natl. Acad. Sci. U.S.A. 87:8506-8510(1990) [PubMed] [Europe PMC] [Abstract]
  37. "Crystal structure of protein C inhibitor provides insights into hormone binding and heparin activation."Structure 11:205-215(2003) [PubMed] [Europe PMC] [Abstract]
  38. "Structure of native protein C inhibitor provides insight into its multiple functions."J. Biol. Chem. 282:13759-13768(2007) [PubMed] [Europe PMC] [Abstract]
  39. "The heparin binding site of protein C inhibitor is protease-dependent."J. Biol. Chem. 283:36039-36045(2008) [PubMed] [Europe PMC] [Abstract]
  40. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  41. ErratumNat. Genet. 23:373-373(1999)