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Testis Specific Serine Kinase 1 (TSSK1)

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TSSK1B; STK22D; SPOGA4; FKSG81; Serine/Threonine Kinase 22D(Spermiogenesis Associated); Testis-specific serine/threonine-protein kinase 1

Testis Specific Serine Kinase 1 (TSSK1)
CCC D394
HGNC 14968
MGI 1347557
PubMed 18533145
RGD 1307352
UniProt Q9BXA7
TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004).Using mouse Tssk1 to search a database, followed by PCR of a testis cDNA library, Hao et al. (2004) cloned human TSSK1. The deduced 367-amino acid protein contains the 12 subdomains characteristic of serine/threonine kinases.
TSSK1 and TSSK2 share 72% amino acid identity overall and 83% identity in the kinase domain. Mouse and human TSSK1 share 85% amino acid identity. Northern blot analysis of human tissues detected TSSK1 transcripts of 1.5 and 2.7 kb in testis only. Real-time PCR revealed abundant TSSK1 expression in testis, lower expression in pancreas, and weak expression in a few other tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testis Specific Serine Kinase 1 (TSSK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testis Specific Serine Kinase 1 (TSSK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testis Specific Serine Kinase 1 (TSSK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testis Specific Serine Kinase 1 (TSSK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testis Specific Serine Kinase 1 (TSSK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testis Specific Serine Kinase 1 (TSSK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testis Specific Serine Kinase 1 (TSSK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testis Specific Serine Kinase 1 (TSSK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testis Specific Serine Kinase 1 (TSSK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testis Specific Serine Kinase 1 (TSSK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Testis Specific Serine Kinase 1 (TSSK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Testis Specific Serine Kinase 1 (TSSK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Testis Specific Serine Kinase 1 (TSSK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Testis Specific Serine Kinase 1 (TSSK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Testis Specific Serine Kinase 1 (TSSK1) ELISA Kit Customized Service Offer
  1. "Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm."Mol. Hum. Reprod. 10:433-444(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate."FEBS Lett. 579:1417-1423(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets."Soc. Reprod. Fertil. Suppl. 63:87-101(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (TSSK1) by the developed assays."J. Med. Chem. 52:4419-4428(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis."Mol. Hum. Reprod. 17:42-56(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]