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Prodynorphin (PDYN)

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PENKB; Preproenkephalin B; Rimorphin; Beta-Neoendorphin; Pro Dynorphin; Leu-enkephalin; Leumorphin; Big dynorphin; Beta-neoendorphin-dynorphin; Preprodynorphin

Prodynorphin (PDYN)
CCC D398
HGNC 8820
MGI 97535
PubMed 19094085
RGD 62054
UniProt P01213
Wiki Prodynorphin
Prodynorphin is a opioid polypeptide hormone involved with chemical signal transduction and cell communication. The gene for prodynorphin is expressed in the endometrium and the striatum, and its gene map locus is 20pter-p12. Prodynorphin is a basic building block of endorphins, the chemical messengers in the brain that appear most heavily involved in the anticipation and experience of pain and the formation of deep emotional bonds, and which are also critical in learning and memory. The prodynorphin enzyme is identical in humans and chimps, but the regulatory promoter sequences have been shown to exhibit marked differences.The gene is thought to influence perception, as well as susceptibility to drug dependence, and is expressed more readily in human beings than in other primates.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prodynorphin (PDYN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prodynorphin (PDYN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prodynorphin (PDYN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prodynorphin (PDYN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prodynorphin (PDYN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prodynorphin (PDYN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prodynorphin (PDYN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prodynorphin (PDYN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prodynorphin (PDYN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prodynorphin (PDYN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prodynorphin (PDYN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prodynorphin (PDYN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prodynorphin (PDYN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prodynorphin (PDYN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prodynorphin (PDYN) ELISA Kit Customized Service Offer
  1. "Isolation and structural organization of the human preproenkephalin B gene."Nature 306:611-614(1983) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "NMR and structural model of dynorphin A (1-17) bound to dodecylphosphocholine micelles."Biochemistry 36:1971-1981(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Dynorphin peptides differentially regulate the human kappa opioid receptor."Life Sci. 80:1439-1448(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor."J. Neurochem. 97:292-301(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Prodynorphin mutations cause the neurodegenerative disorder spinocerebellar ataxia type 23."Am. J. Hum. Genet. 87:593-603(2010) [PubMed] [Europe PMC] [Abstract]
  9. ErratumAm. J. Hum. Genet. 87:736-736(2010)
  10. "Perturbations of model membranes induced by pathogenic dynorphin A mutants causing neurodegeneration in human brain."Biochem. Biophys. Res. Commun. 411:111-114(2011) [PubMed] [Europe PMC] [Abstract]
  11. "The frequency of spinocerebellar ataxia type 23 in a UK population."J. Neurol. 260:856-859(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Identification and characterization of novel PDYN mutations in dominant cerebellar ataxia cases."J. Neurol. 260:1807-1812(2013) [PubMed] [Europe PMC] [Abstract]