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Phosphofructokinase, Liver (PFKL)

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PFK-B; 6-phosphofructokinase type B; Phosphofructo-1-kinase isozyme B; Phosphohexokinase

Phosphofructokinase, Liver (PFKL)
CCC D406
HGNC 8876
MGI 97547
PubMed 2139864
RGD 3311
UniProt P17858
Wiki PFKL
The PFKL gene encodes the liver isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. Mammalian PFK is a tetramer made up of various combinations of 3 subunits: muscle (PFKM), liver (PFKL), and platelet (PFKP), the genes for which are located on chromosomes 12q13, 21q22, and 10p, respectively. The composition of the tetramers differs according to the tissue type. Muscle and liver PFK are a homotetramers of 4M and 4L subunits, respectively. Erythrocytes contain both L and M subunits, which randomly tetramerize to form M4, L4, M3L, M2L2, and ML3 hybrid forms of the holoenzyme.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD406Hu01 Recombinant Phosphofructokinase, Liver (PFKL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Phosphofructokinase, Liver (PFKL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphofructokinase, Liver (PFKL) Polyclonal Antibody Customized Service Offer
Assay Kits SED406Hu ELISA Kit for Phosphofructokinase, Liver (PFKL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphofructokinase, Liver (PFKL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphofructokinase, Liver (PFKL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphofructokinase, Liver (PFKL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphofructokinase, Liver (PFKL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphofructokinase, Liver (PFKL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD406Ra01 Recombinant Phosphofructokinase, Liver (PFKL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD406Ra01 Polyclonal Antibody to Phosphofructokinase, Liver (PFKL) WB; IHC; ICC; IP.
MAD406Ra21 Monoclonal Antibody to Phosphofructokinase, Liver (PFKL) WB; IHC; ICC; IP.
Assay Kits SED406Ra ELISA Kit for Phosphofructokinase, Liver (PFKL) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The primary structure of human liver type phosphofructokinase and its comparison with other types of PFK."DNA 8:733-743(1989) [PubMed] [Europe PMC] [Abstract]
  2. "The structure of the human liver-type phosphofructokinase gene."Genomics 7:47-56(1990) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]