≡

Gamma-Glutamyl Carboxylase (gGCX)

[Edit]

GC; VKCFD1; Vitamin K-Dependent Gamma-Carboxylase; Peptidyl-glutamate 4-carboxylase; Vitamin K gamma glutamyl carboxylase

Gamma-Glutamyl Carboxylase (gGCX)
CCC D409
HGNC 4247
MGI 1927655
PubMed 9845520
RGD 68383
UniProt P38435
Wiki GGCX
Gamma-glutamyl carboxylase is an enzyme catalyzes the posttranslational modification of vitamin K-dependent proteins. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis.Most gla domain-containing proteins depend on this carboxylation reaction for posttranslational modification. In humans, the gamma-glutamyl carboxylase enzyme is most highly expressed in the liver.
Gamma-glutamyl carboxylase is an enzyme which oxidizes Vitamin K hydroquinone to Vitamin K 2,3 epoxide, while simultaneously adding CO2 to protein-bound glutamic acid (abbreviation = Glu) to form gamma-carboxyglutamic acid (also called gamma-carboxyglutamate, abbreviation = Gla).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gamma-Glutamyl Carboxylase (gGCX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gamma-Glutamyl Carboxylase (gGCX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gamma-Glutamyl Carboxylase (gGCX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gamma-Glutamyl Carboxylase (gGCX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gamma-Glutamyl Carboxylase (gGCX) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gamma-Glutamyl Carboxylase (gGCX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gamma-Glutamyl Carboxylase (gGCX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gamma-Glutamyl Carboxylase (gGCX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gamma-Glutamyl Carboxylase (gGCX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gamma-Glutamyl Carboxylase (gGCX) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gamma-Glutamyl Carboxylase (gGCX) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gamma-Glutamyl Carboxylase (gGCX) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gamma-Glutamyl Carboxylase (gGCX) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gamma-Glutamyl Carboxylase (gGCX) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gamma-Glutamyl Carboxylase (gGCX) ELISA Kit Customized Service Offer
  1. "Cloning and expression of the cDNA for human gamma-glutamyl carboxylase."Science 254:1634-1636(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic sequence and transcription start site for the human gamma-glutamyl carboxylase."Blood 89:4058-4062(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A topological study of the human gamma-glutamyl carboxylase."Blood 96:973-978(2000) [PubMed] [Europe PMC] [Abstract]
  7. "A novel fluorescence assay to study propeptide interaction with gamma-glutamyl carboxylase."Biochemistry 40:11723-11733(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Determination of disulfide bond assignment of human vitamin K-dependent gamma-glutamyl carboxylase by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry."J. Biol. Chem. 278:45468-45475(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The vitamin K-dependent carboxylase."Annu. Rev. Nutr. 25:127-149(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Bronsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation."Biochemistry 45:13239-13248(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "A missense mutation in gamma-glutamyl carboxylase gene causes combined deficiency of all vitamin K-dependent blood coagulation factors."Blood 92:4554-4559(1998) [PubMed] [Europe PMC] [Abstract]
  16. "Novel mutation in the gamma-glutamyl carboxylase gene resulting in congenital combined deficiency of all vitamin K-dependent blood coagulation factors."Blood 96:3650-3652(2000) [PubMed] [Europe PMC] [Abstract]
  17. "Expression and characterization of the naturally occurring mutation L394R in human gamma-glutamyl carboxylase."J. Biol. Chem. 275:32572-32577(2000) [PubMed] [Europe PMC] [Abstract]
  18. "Compound heterozygous mutations in the gamma-glutamyl carboxylase gene cause combined deficiency of all vitamin K-dependent blood coagulation factors."Br. J. Haematol. 126:546-549(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity."J. Invest. Dermatol. 127:581-587(2007) [PubMed] [Europe PMC] [Abstract]