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Myosin VA (MYO5A)

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GS1; MYH12; MYO5; MYOXIN; MYR12; myosin V; myosin Va; Myosin,Heavy Polypeptide Kinase; Myosin Heavy Chain 12; Myoxin; Myosin V; Dilute myosin heavy chain, non-muscle

Myosin VA (MYO5A)
CCC D424
HGNC 7602
MGI 105976
PubMed 15550542
RGD 3143
UniProt Q9Y4I1
Wiki MYO5A
MYO5A is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation.
The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD424Hu01 Recombinant Myosin VA (MYO5A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD424Hu01 Polyclonal Antibody to Myosin VA (MYO5A) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Myosin VA (MYO5A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin VA (MYO5A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD424Mu01 Recombinant Myosin VA (MYO5A) Positive Control; Immunogen; SDS-PAGE; WB.
RPD424Mu02 Recombinant Myosin VA (MYO5A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD424Mu01 Polyclonal Antibody to Myosin VA (MYO5A) WB; IHC; ICC; IP.
PAD424Mu02 Polyclonal Antibody to Myosin VA (MYO5A) WB; IHC; ICC; IP.
Assay Kits SED424Mu ELISA Kit for Myosin VA (MYO5A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD424Ra01 Recombinant Myosin VA (MYO5A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Myosin VA (MYO5A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin VA (MYO5A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin VA (MYO5A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin VA (MYO5A) ELISA Kit Customized Service Offer
  1. "Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene."Nat. Genet. 16:289-292(1997) [PubMed] [Europe PMC] [Abstract]
  2. ErratumNat. Genet. 23:373-373(1999)
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene."Genomics 19:407-416(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and regional assignment of the human myosin heavy chain 12 (MYH12) gene to chromosome band 15q21."Cytogenet. Cell Genet. 69:53-58(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Myosin-V is a processive actin-based motor."Nature 400:590-593(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions."FEBS Lett. 517:233-238(2002) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes."J. Cell Biol. 198:545-560(2012) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Arg-Cys substitution at codon 1246 of the human myosin Va gene is not associated with Griscelli syndrome."J. Invest. Dermatol. 114:731-733(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Two genes are responsible for Griscelli syndrome at the same 15q21 locus."Genomics 63:299-306(2000) [PubMed] [Europe PMC] [Abstract]
  17. "Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A."Am. J. Hum. Genet. 71:407-414(2002) [PubMed] [Europe PMC] [Abstract]
  18. ErratumAm. J. Hum. Genet. 71:1007-1007(2002)
  19. "Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1)."J. Clin. Invest. 112:450-456(2003) [PubMed] [Europe PMC] [Abstract]