≡

Myosin VB (MYO5B)

[Edit]

Myosin VB (MYO5B)
CCC D456
HGNC 7603
MGI 106598
PubMed 20186687
RGD 621347
UniProt Q9ULV0
Wiki MYO5B
Recent evidence suggests that Myosin VB is related to the creation of memories.KIAA1119. The deduced 1,260-amino acid protein is 88% identical to rat Myr6. RT-PCR analysis detected wide expression of KIAA1119, with highest levels in liver, followed by kidney.
Roland et al. (2007) demonstrated the interaction of MYO5B with RAB8A in yeast 2-hybrid assays, and confirmed the interaction of MYO5B with RAB11A and RAB8A in vivo using fluorescent resonant energy transfer techniques.Muller et al. (2008) noted that MYO5B is required for the recycling of transferrin receptor back to the plasma membrane through an endocytotic recycling compartment in nonpolarized, but not polarized, cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin VB (MYO5B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin VB (MYO5B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin VB (MYO5B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin VB (MYO5B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin VB (MYO5B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin VB (MYO5B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin VB (MYO5B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin VB (MYO5B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin VB (MYO5B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin VB (MYO5B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin VB (MYO5B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin VB (MYO5B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin VB (MYO5B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin VB (MYO5B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin VB (MYO5B) ELISA Kit Customized Service Offer
  1. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and characterization of a family of Rab11-interacting proteins."J. Biol. Chem. 276:39067-39075(2001) [PubMed] [Europe PMC] [Abstract]
  6. "CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling."Mol. Biol. Cell 16:2470-2482(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells."J. Biol. Chem. 282:23725-23736(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface."J. Biol. Chem. 284:22481-22490(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease."J. Pediatr. Gastroenterol. Nutr. 52:307-313(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization."Proc. Natl. Acad. Sci. U.S.A. 108:2789-2794(2011) [PubMed] [Europe PMC] [Abstract]
  13. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Navajo microvillous inclusion disease is due to a mutation in MYO5B."Am. J. Med. Genet. A 146A:3117-3119(2008) [PubMed] [Europe PMC] [Abstract]
  15. "MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity." Nat. Genet. 40:1163-1165(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Loss-of-function of MYO5B is the main cause of microvillus inclusion disease: 15 novel mutations and a CaCo-2 RNAi cell model." Hum. Mutat. 31:544-551(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Microvillus inclusion disease: loss of Myosin vb disrupts intracellular traffic and cell polarity."Traffic 15:22-42(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease."J. Clin. Invest. 124:2947-2962(2014) [PubMed] [Europe PMC] [Abstract]