≡

Myosin Regulatory Light Chain Interacting Protein (MYLIP)

[Edit]

MIR; IDOL; BZF1; Inducible Degrader Of The LDL Receptor; E3 ubiquitin-protein ligase MYLIP

Myosin Regulatory Light Chain Interacting Protein (MYLIP)
CCC D460
HGNC 21155
MGI 2388271
PubMed 21765216
RGD 1305761
UniProt Q8WY64
Wiki MYLIP
MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation. The expression of IDOL is induced by the sterol-ativated liver X receptor.
MYLIP belongs to the ezrin (VIL2)-radixin (RDX)-moesin (MSN) (ERM) family of cytoskeletal effector proteins that link actin to membrane-bound proteins at the cell surface (Olsson et al., 1999).
The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin Regulatory Light Chain Interacting Protein (MYLIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin Regulatory Light Chain Interacting Protein (MYLIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin Regulatory Light Chain Interacting Protein (MYLIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin Regulatory Light Chain Interacting Protein (MYLIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin Regulatory Light Chain Interacting Protein (MYLIP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin Regulatory Light Chain Interacting Protein (MYLIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin Regulatory Light Chain Interacting Protein (MYLIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin Regulatory Light Chain Interacting Protein (MYLIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin Regulatory Light Chain Interacting Protein (MYLIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin Regulatory Light Chain Interacting Protein (MYLIP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Myosin Regulatory Light Chain Interacting Protein (MYLIP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Myosin Regulatory Light Chain Interacting Protein (MYLIP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Myosin Regulatory Light Chain Interacting Protein (MYLIP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Myosin Regulatory Light Chain Interacting Protein (MYLIP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Myosin Regulatory Light Chain Interacting Protein (MYLIP) ELISA Kit Customized Service Offer
  1. "MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth."J. Biol. Chem. 274:36288-36292(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR."FEBS Lett. 553:195-199(2003) [PubMed] [Europe PMC] [Abstract]
  7. "MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain."J. Biol. Chem. 278:35412-35420(2003) [PubMed] [Europe PMC] [Abstract]
  8. "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor."Science 325:100-104(2009) [PubMed] [Europe PMC] [Abstract]
  9. "The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2."J. Biol. Chem. 285:19720-19726(2010) [PubMed] [Europe PMC] [Abstract]
  10. "FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors."Proc. Natl. Acad. Sci. U.S.A. 108:20107-20112(2011) [PubMed] [Europe PMC] [Abstract]
  11. "The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor."Genes Dev. 25:1262-1274(2011) [PubMed] [Europe PMC] [Abstract]